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作者

Xia, ZY Yang, H Yuan, XC Wang, JY Zhang, SG Zhang, LY Qu, Y Chen, J Jiao, LQ Wang, LX

作者单位

Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2678, Australia Liaocheng Peoples Hosp, Dept Magnet Resonance, Liaocheng, Shandong, Peoples R China Liaocheng Peoples Hosp, Dept Neurol, Liaocheng, Shandong, Peoples R China Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Shandong, Peoples R China Liaocheng Peoples Hosp, Dept Neurosurg, Liaocheng, Shandong, Peoples R China Taishan Med Univ, Liaocheng Clin Sch, Liaocheng, Shandong, Peoples R China Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China Third Peoples Hosp Liaocheng, Dept Neurol, Liaocheng, Shandong, Peoples R China

刊名

VASA. Zeitschrift Fur Gefasskrankheiten

年份

2017

卷号

Vol.46 No.4

页码

283-290

ISSN

0301-1526;1664-2872

关键词

ARTERY ENDARTERECTOMY STENOSIS CLASSIFICATION STROKE NEOVASCULARIZATION VULNERABILITY INFLAMMATION LESIONS STRESS

摘要

Background: This study aimed to utilize high-resolution magnetic resonance imaging to investigate the characteristics of stable and vulnerable carotid arteriosclerotic plaques, with correlations to histopathological findings. Patients and Methods: High-resolution MRI was performed in 817 patients, using three-dimensional magnetic resonance angiography. Plaque composition was evaluated by measuring the areas occupied by calcification, a lipid-rich necrotic core, intra-plaque haemorrhage, and fib...更多

Background: This study aimed to utilize high-resolution magnetic resonance imaging to investigate the characteristics of stable and vulnerable carotid arteriosclerotic plaques, with correlations to histopathological findings. Patients and Methods: High-resolution MRI was performed in 817 patients, using three-dimensional magnetic resonance angiography. Plaque composition was evaluated by measuring the areas occupied by calcification, a lipid-rich necrotic core, intra-plaque haemorrhage, and fibrous cap rupture. Plaque morphology was analysed by measuring vessel wall area, thickness, and luminal area at the bifurcation of the common carotid artery. Plaque tissues were sampled during carotid endarterectomy and examined using haematoxylin-eosin, Oil Red O, Masson trichrome staining, and immunohistochemical staining for CD68. Results: Patients were divided into stable plaque group and vulnerable plaque group , based on intraoperative observations and postoperative histopathological findings. Compared to the stable plaque group, the vulnerable plaque group exhibited increased vessel wall areas and thickness, and decreased mean luminal areas . Conclusions: Stable and vulnerable carotid plaques had different morphologies and compositions. High-resolution MRI can assess such differences qualitatively and quantitatively in vivo and provide guidance for risk stratification and management.收起

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