The Synergistic Effects Study of C-myc and C-erbB-2 in the Carcinogenesis of Gastric Carcinoma

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作者: Keqiang Wang Jiangang Liu Yanchao Duan Shengyi Dongye Jiafeng Wu Yiren Wang Zhenzhong Liu Guoxin Han

作者单位: Departments of 1Clinical Laboratory, Affiliated Hospital of Taishan Medical University, Tai’an, China . Hematology, Affiliated Hospital of Taishan Medical University, Tai’an, China . General Surgery, Affiliated Hospital of Taishan Medical University, Tai’an, China . Medical Laboratory Class, Grade 2016, Medical College, Qingdao University, Qingdao, China . Pathology, Affiliated Hospital of Taishan Medical University, Tai’an, China .

摘要: Objective: To study the significance of c-myc and c-erbB-2 oncogene expression in gastric cancer. Methods: 81 gastric cancer specimens were detected for c-myc and c-erbB-2 oncogene amplification using non-radioactive in situ hybridization method. Results: The amplification rates for c-myc and c-erbB-2 were 67.9% and 50.6% respectively, and there were significant correlation in the amplification of these two genes . Conclusions: The amplification of c-myc and c-erbB-2 may play an important role i...更多; Objective: To study the significance of c-myc and c-erbB-2 oncogene expression in gastric cancer. Methods: 81 gastric cancer specimens were detected for c-myc and c-erbB-2 oncogene amplification using non-radioactive in situ hybridization method. Results: The amplification rates for c-myc and c-erbB-2 were 67.9% and 50.6% respectively, and there were significant correlation in the amplification of these two genes . Conclusions: The amplification of c-myc and c-erbB-2 may play an important role in gastric cancer development, and these two genes may have synergistic effect.收起

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