Capital Med Univ, Beijing Key Lab Clin Epidemiol, Sch Publ Hlth, Beijing, Peoples R China Capital Medical UniversityTaishan Med Univ, Sch Publ Hlth, Tai An, Shandong, Peoples R China Shandong First Medical University & Shandong Academy of Medical SciencesEdith Cowan Univ, Sch Med & Hlth Sci, Perth, WA, Australia Edith Cowan University
Background: Esophageal cancer causes more than 400 thousand deaths per year, and half of them occur in China. There are discrepancies regarding the survival of EC patients between population-based surveillance studies and hospital-based studies. Objectives: We aimed to synthesize the survival data from hospital-based EC studies in the Chinese population from 2000 to 2018 and to compare the survival rates between EC patients with different clinical classifications. Methods: The protocol of this ...更多
Background: Esophageal cancer causes more than 400 thousand deaths per year, and half of them occur in China. There are discrepancies regarding the survival of EC patients between population-based surveillance studies and hospital-based studies. Objectives: We aimed to synthesize the survival data from hospital-based EC studies in the Chinese population from 2000 to 2018 and to compare the survival rates between EC patients with different clinical classifications. Methods: The protocol of this systematic review was registered in PROSPERO . We searched Embase, PubMed, CNKI, and Wanfang databases for studies published between January 1, 2000 and December 31, 2018. We calculated the pooled survival rates and 95% confidence intervals by Stata software . Results: Our literature search identified 933 studies, of which 331 studies with 79,777 EC patients met the inclusion criteria and were included in meta-analyses. The pooled survival rates were 74.1% for 1-year survival, 49.0% for 2-years survival, 46.0% for 3-years survival, and 40.1% for 5-years survival. An increased tendency toward EC survival was verified from 2000 to 2018. In addition, discrepancies were observed between EC patients with different clinical classifications . Conclusions: Our findings showed a higher survival rate in hospital-based studies than population-based surveillance studies. Although this hospital-based study is subject to potential representability and publication bias, it offers insight into the prognosis of patients with EC in China.收起
