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作者

Cheng Qiu, Lin Cheng, Haodong Hou, Tianyi Liu, Bohan Xu, Xing Xiao, Zhankui Wang, Qing Wang

作者单位

Department of Orthopaedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, P. R. China. Department of Rheumatology and Autoimmunology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, 12589Shandong University, Shandong University, Jinan, Shandong, P. R. China. Affiliations Department of Rheumatology and Autoimmunology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, P. R. China. Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, P. R. China. Department of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, 12589Shandong University, Shandong University, Jinan, Shandong, P. R. China. Cheeloo College of Medicine, 12589Shandong University, Shandong University, Jinan, Shandong, P. R. China.

刊名

The Journal of international medical research

年份

2021

卷号

Vol.49 No.12

ISSN

1473-2300

关键词

Synovitis acne and osteitis (SAPHO) syndrome bone scintigraphy femur hyperostosis inflammation osteomyelitis pustulosis skin.

摘要

Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome is an umbrella term covering a constellation of bone lesions and skin manifestations, but has rarely been clarified in the clinic. We report a 28-year-old woman who had initial onset of SAPHO syndrome with involvement of the femur, and she experienced a tortuous diagnostic course. We also performed a literature review of SAPHO syndrome cases involving the femur and summarize several empirical conclusions by integrating previous fi...更多

Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome is an umbrella term covering a constellation of bone lesions and skin manifestations, but has rarely been clarified in the clinic. We report a 28-year-old woman who had initial onset of SAPHO syndrome with involvement of the femur, and she experienced a tortuous diagnostic course. We also performed a literature review of SAPHO syndrome cases involving the femur and summarize several empirical conclusions by integrating previous findings with our case. Furthermore, we propose our perspective that ailment of the skin caused by infection of pathogens might be the first hit for triggering or perpetuating the activation of the immune system. As a result, musculoskeletal manifestations are probably the second hit by crosstalk of an autoimmune reaction. The skin manifestations preceding bone lesions can be well explained. Current interventions for SAPHO syndrome remain controversial, but drugs aiming at symptom relief could serve as the first preference for treatment. An accurate diagnosis and appropriate treatment can cure patients in a timely manner. Although the pathogenesis of SAPHO syndrome remains to be determined, physicians and surgeons still need to heighten awareness of this entity to avoid invasive procedures, such as frequent biopsies or nonessential ostectomy.收起

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