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作者

Lei Wang Maya Rajavel Ching-Wen Wu Chuanzhen Zhang Morgan Poindexter Ciara Fulgar Tiffany Mar Jasmine Singh Jaspreet K. Dhillon Jingjing Zhang Yinyu Yuan Radek Abarca Wei Li Kent E. Pinkerton

作者单位

Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, China ³a Center for Health and the Environment, University of California, Davis, CA, USA ^{4 Department of Pediatrics, University of California, Davis, CA, USA 5a Center for Health and the Environment, University of California, Davis, CA, USA Western China School of Public Health Department of Occupational and Environmental Health Sichuan University, Chengdu, China 1a Center for Health and the Environment, University of California, Davis, CA, USA 2a Center for Health and the Environment, University of California, Davis, CA, USA School of Control Science and Engineering, Shandong University, Jinan, China}

刊名

Journal of Toxicology and Environmental Health, Part A

年份

2022

卷号

Vol.85 No.11

页码

439-456

ISSN

1528-7394

关键词

Environmental tobacco smoke lung immune response influenza virus

摘要

Limited data are available on the effects of perinatal environmental tobacco smoke exposure for early childhood influenza infection. The aim of the present study was to examine whether perinatal versus adult ETS exposure might provoke more severe systemic and pulmonary innate immune responses in mice inoculated with influenza A/Puerto Rico/8/34 virus compared to phosphate-buffered saline . BALB/c mice were exposed to filtered air or ETS for 6 weeks during the perinatal or adult period of life...更多

Limited data are available on the effects of perinatal environmental tobacco smoke exposure for early childhood influenza infection. The aim of the present study was to examine whether perinatal versus adult ETS exposure might provoke more severe systemic and pulmonary innate immune responses in mice inoculated with influenza A/Puerto Rico/8/34 virus compared to phosphate-buffered saline . BALB/c mice were exposed to filtered air or ETS for 6 weeks during the perinatal or adult period of life. Immediately following the final exposure, mice were intranasally inoculated with IAV or PBS. Significant inflammatory effects were observed in bronchoalveolar lavage fluid of neonates inoculated with IAV compared to PBS , and in the lung parenchyma of neonates administered ETS+IAV versus FA+IAV. Type I and III interferons were also elevated in the spleens of neonates, but not adults with ETS+IAV versus FA+IAV exposure. Both IAV-inoculated neonate groups exhibited significantly more CD4 T cells and increasing numbers of CD8 and CD25 T cells in lungs relative to their adult counterparts. Taken together, these results suggest perinatal ETS exposure induces an exaggerated innate immune response, which may overwhelm protective anti-inflammatory defenses against IAV, and enhances severity of infection at early life stages .收起

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