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作者

Yang, Yue Song, Lijie Cao, Jingyu Liu, Jing Wang, Dongxu Wong, Linda L. Zhao, Lei

作者单位

^eDepartment of Biostatistics, School of Public Health, Shandong University, 44 Wenhua West Road, Lixia District, Jinan, China ⁴Department of Hepatobiliary Surgery, Affiliated Hospital, Qingdao University, 1677 Wutaishan Road, Huangdao District, Qingdao, China ³Department of Oncology, First Affiliated Hospital, Zhengzhou University, ²Department of Hepatobiliary Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, 440 Jiyan road, Huaiyin District, Jinan, China Jianshe East Road, Erqi District, Zhengzhou, China ^gDepartment of Surgery, University of Hawaii, School of Medicine, 3430 Keahi Place, Honolulu, HI 96822, United States Shuaifuyuan Wangfujing Dongcheng District, Beijing, China ¹Shandong First Medical University, Shandong Academy of Medical Sciences, 6699 Qingdao road, Huaiyin District, Jinan, China ^fDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No

刊名

Journal of Cancer

年份

2021

卷号

Vol.12 No.5

页码

1398-1405

ISSN

1837-9664

关键词

Chronic hepatitis B (CHB) Colorectal liver metastasis (CRLM) Hepatitis B e antigen (HBeAg) Risk

分类号

616.992

摘要

Background: A considerable part of colorectal cancer patients also have chronic hepatitis B , esp. in Asia. The effect of concomitant active CHB on the hazard of colorectal liver metastasis remains unclear. To evaluate the effect of concomitant active CHB on the risk of CRLM. Methods: The medical record of all newly diagnosed CRC patients who were hospitalized to the three hospitals between January 2010 to January 2016 were reviewed, the prevalence of synchronous CRLM were retrospectively stu...更多

Background: A considerable part of colorectal cancer patients also have chronic hepatitis B , esp. in Asia. The effect of concomitant active CHB on the hazard of colorectal liver metastasis remains unclear. To evaluate the effect of concomitant active CHB on the risk of CRLM. Methods: The medical record of all newly diagnosed CRC patients who were hospitalized to the three hospitals between January 2010 to January 2016 were reviewed, the prevalence of synchronous CRLM were retrospectively studied. Totally 7187 cases of newly diagnosed CRC, including 368 cases with concomitant CHB were recruited. The prevalence of synCRLM in HBsAg/HBeAg patients was compared to that in HBsAg/HBeAg- patients. Significant risk factors for synCRLM were analyzed by logistic regression analysis. Results: The overall prevalence of synCRLM was 8.72% and was significantly higher in HBsAg+ patients than HBsAg- patients .In 368 HBsAg patients, 365 patients also had HBeAg information. synCRLM was also more prevalent inHBsAg/HBeAg patients compared to HBsAg/HBeAg- patients . In univariate and multivariate logistic regression analysis, HBeAg positivity was the second strongest predictor of synCRLM after CEA. . Conclusions: HBeAg positivity is a clinical risk factor for CRLM that can be readily identified and addressed. Whether anti-CHB treatment can decrease the risk of CRLM worth carefully-designed prospective trials to define. © The author. This is an open access article distributed under the terms of the Creative Commons Attribution License . See http://ivyspring.com/terms for full terms and conditions.收起

学科

【SCI学科】ONCOLOGY 【ESI学科】CLINICAL MEDICINE

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