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作者

Hua-Zhen Tang Zhen-Peng Yang Shuai Lu Bing Wang Yu-Ying Wang Xi-Bo Sun Jin-Xiu Qu Ben-Qiang Rao

作者单位

Affiliations ¹ Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. ² Department of Gastrointestinal Surgery, Key Laboratory of Cancer FSMP for State Market Regulation, Beijing 100038, China. ³ Department of Breast Surgery, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, Shandong Province, China. ⁴ Department of Gastrointestinal Surgery, Key Laboratory of Cancer FSMP for State Market Regulation, Beijing 100038, China. raobenqiang@bjsjth.cn.

刊名

World journal of gastrointestinal oncology

年份

2023

卷号

Vol.15 No.1

页码

90-101

ISSN

1948-5204

关键词

Colorectal cancer Heat-clearing and detoxifying therapy Network pharmacology Transcriptomics.

摘要

Background: Heat-clearing and detoxifying drugs has protective effect on colorectal cancer . Given the complicated features of Traditional Chinese medicine formulas, network pharmacology is an effective approach for studying the multiple interactions between drugs and diseases. Aim: To systematically explore the anticancer mechanism of heat-clearing and detoxifying drug JC724. Methods: This study obtained the active compounds and their targets in JC724 from Traditional Chinese Medicine System Ph...更多

Background: Heat-clearing and detoxifying drugs has protective effect on colorectal cancer . Given the complicated features of Traditional Chinese medicine formulas, network pharmacology is an effective approach for studying the multiple interactions between drugs and diseases. Aim: To systematically explore the anticancer mechanism of heat-clearing and detoxifying drug JC724. Methods: This study obtained the active compounds and their targets in JC724 from Traditional Chinese Medicine System Pharmacology Database. In addition, the CRC targets were obtained from Drugbank, TTD, DisGeNET and GeneCards databases. We performed transcriptome analysis of differentially expressed genes in CRC treated with JC724. Venn diagram was used to screen the JC724-CRC intersection targets as candidate targets. Core targets were selected by protein-protein interaction network and herb ingredient-target-disease network analysis. The functional and pathway of core targets were analysed by enrichment analysis. Results: We found 174 active ingredients and 283 compound targets from JC724. 940 CRC-related targets were reserved from the four databases and 304 CRC differentially expressed genes were obtained by transcriptome analysis. We constructed the network and found that the five core ingredients were quercetin, β Beta sitosterol, wogonin, kaempferol and baicalein. The core JC724-CRC targets were CYP1A1, HMOX1, CXCL8, NQO1 and FOSL1. JC724 acts on multiple signaling pathways associated with CRC, including the Nrf2 signaling pathway, oxidative stress, and the IL-17 signaling pathway. Conclusion: In this study, we systematically analyzed the active ingredients, core targets and main mechanisms of JC724 in the treatment of CRC. This study could bring a new perspective to the heat-clearing and detoxifying therapy of CRC.收起

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