Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015

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作者: Bi, Yuhai Chen, Jianjun Zhang, Zhenjie Li, Mingxin Cai, Tianlong Sharshov, Kirill Susloparov, Ivan Shestopalov, Alexander Wong, Gary He, Yubang

作者单位: ⁹ Zhejiang Univ, Chinese Ctr Dis Control & Prevent China CDC, Off Director Gen, Hangzhou 310058, Zhejiang, Peoples R China ⁸ State Forestry Adm, Qinghai Lake Natl Nat Reserve, Xining 810007, Peoples R China ⁵ Chinese Acad Sci, Inst Zool, CAS Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China ² Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China ¹⁰ Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China ⁶ Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China ⁷ Novosibirsk State Univ, Res Inst Expt & Clin Med, Novosibirsk 630090, Russia ¹ Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, State Key Discipline Infect Dis, Shenzhen 518112, Peoples R China ⁴ Taishan Med Coll, Inst Pathogen Biol, Taishan 271000, Peoples R China ³ Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol CASPMI, Beijing 100101, Peoples R China

关键词: A VIRUS MOLECULAR-BASIS A(H5N1) VIRUS AMINO-ACID HOST-RANGE OUTBREAKS HEMAGGLUTININ VIRULENCE POULTRY PROTEIN

摘要: A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain . Further analysis showed that similar viruses have been circulating in wild...更多; A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain . Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai , Bulgaria and Romania , as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans.收起

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