Thiol-yne click post-synthesis of phenylboronic acid-functionalized magnetic cyclodextrin microporous organic network for selective and efficient extraction of antiepileptic drugs
1School of Pharmaceutical Sciences & Institute of Materia Medica, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
刊名
Talanta
年份
2024
页码
126440
ISSN
0039-9140
分类号
543
摘要
Owing to their incomplete digestion in the human body and inadequate removal by sewage treatment plants, antiepileptic drugs accumulate in water bodies, potentially affecting the exposed humans and aquatic organisms. Therefore, sensitive and reliable detection methods must be urgently developed for monitoring trace AEDs in environmental water samples. Herein, a novel phenylboronic acid-functionalized magnetic cyclodextrin microporous organic network was designed and synthesized via the thiol-y...更多
Owing to their incomplete digestion in the human body and inadequate removal by sewage treatment plants, antiepileptic drugs accumulate in water bodies, potentially affecting the exposed humans and aquatic organisms. Therefore, sensitive and reliable detection methods must be urgently developed for monitoring trace AEDs in environmental water samples. Herein, a novel phenylboronic acid-functionalized magnetic cyclodextrin microporous organic network was designed and synthesized via the thiol-yne click post-modification strategy for selective and efficient magnetic solid-phase extraction of trace AEDs from complex sample matrices through the specific B-N coordination, π-π, hydrogen bonding, electrostatic, and host-guest interactions. FeO@CD-MON-PBA exhibited a large surface area , rapid magnetic responsiveness , good stability and reusability , and abundant binding sites for AEDs. Under optimal extraction conditions, the proposed FeO@CD-MON-PBA-MSPE-HPLC-UV method exhibited a wide linear range , low limits of detection and quantitation , good anti-interference ability, and large enrichment factors for four typical AEDs. This work confirmed the feasibility of the thiol-yne click post-synthesis strategy for constructing novel and efficient multifunctional magnetic CD-MONs for sample pretreatment and elucidated the significance of B-N coordination between PBA and N-containing AEDs.收起
发文期刊《Thiol-yne click post-synthesis of phenylboronic acid-functionalized magnetic cyclodextrin microporous organic network for selective and efficient extraction of antiepileptic drugs》历年引证文献趋势图
