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作者

Bo Wang, Liuyang Feng, Lei Xu, Hao Gao, Xiaoyu Luo, Nan Qi

作者单位

Frontiers Science Center for Nonlinear Expectations, Ministry of Education, Qingdao, 266237, China. Electronic address: Nan.Qi@sdu.edu.cn. Affiliations ¹ Research Center for Mathematics and Interdisciplinary Sciences, Shandong University, Qingdao, 266237, China. ² School of Mathematics and Statistics, University of Glasgow, Glasgow, G12 8QQ, UK. ³ Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China. ⁴ Research Center for Mathematics and Interdisciplinary Sciences, Shandong University, Qingdao, 266237, China

刊名

Computers in biology and medicine

年份

2024

卷号

Vol.185

页码

109450

ISSN

1879-0534

关键词

Fluid–structure interaction Immersed-boundary finite element method Three-dimensional framework Venous valve.

摘要

Research on venous hemodynamics is pivotal for unravelling venous diseases, including varicose veins and deep vein thrombosis, essential for clinical management, treatment and artificial valve design. In this study, a three-dimensional numerical simulation, employing the immersed boundary/finite element method, is constructed to explore the fluid-structure interaction between intravenous blood and venous valves. A hyperelastic constitutive model is used to capture the incompressible, nonlinear...更多

Research on venous hemodynamics is pivotal for unravelling venous diseases, including varicose veins and deep vein thrombosis, essential for clinical management, treatment and artificial valve design. In this study, a three-dimensional numerical simulation, employing the immersed boundary/finite element method, is constructed to explore the fluid-structure interaction between intravenous blood and venous valves. A hyperelastic constitutive model is used to capture the incompressible, nonlinear mechanical response. Our findings reveal the periodic characteristics of valve movement and intravenous blood flow throughout the cardiac cycle, alongside quantified physiological parameters such as blood pressure, flow rate, geometric orifice area, and stress-strain distribution on venous valve surfaces. The study unveils a significant correlation between dynamic valve motion and vortices within the venous sinus. Stress and strain concentrate primarily at the free edge of venous valves, which is in contrast to 2D modelling. Moreover, increased hydrostatic venous pressure is found to be the key to venous vessel dilation. The effects of fibrosis and atrophy of venous valves on venous hemodynamics are compared and analysed. This FSI numerical study introduces a fully 3D framework for modelling the venous system, expected to provide crucial references for understanding the development and mechanism underlying venous diseases, thereby furnishing a scientific underpinning for their prevention, diagnosis, and treatment.收起

文献类型

期刊