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作者

Yan He, Fernando Gomes Romeiro, Mingyu Sun, Fanpu Ji, Qiang Zhu, Yingli He, Dapeng Ma, Shanshan Yuan, Xiaofeng Liu, Cyriac Abby Philips, Metin Basaranoglu, Nahum Méndez-Sánchez, Kanokwan Pinyopornpanish, Yiling Li, Yunhai Wu, Ling Yang, Lichun Shao, Andrea Mancuso, Yu Chen, Frank Tacke, Su Lin, Lei Liu, Bimin Li, Xingshun Qi

作者单位

Affiliations ¹ Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of China Medical University), Shenyang, China. ² Botucatu Medical School, São Paulo State University, Botucatu, Brazil. ³ Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. ⁴ Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. ⁵ Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China. ⁶ Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. ⁷ Department of Critical Care Medicine, The Sixth People's Hospital of Dalian, Dalian, China. ⁸ Department of Gastroenterology, Xi'an Central Hospital, Xi'an, China. ⁹ Department of Gastroenterology, The 960th Hospital of Chinese PLA, Jinan, Shandong, China. ¹⁰ Department of Clinical and Translational Hepatology, The Liver Institute, Center of Excellence in GI Sciences, Rajagiri Hospital, Kerala, India. ¹¹ Gastroenterology and Hepatology, Bezmialem Vakif University, Istanbul, Turkey. ¹² Medica Sur Clinic, National Autonomous University of Mexico, Mexico City, Mexico. ¹³ Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. ¹⁴ Department of Gastroenterology, The First Hospital of China Medical University, Shenyang, China. ¹⁵ Department of Critical Care Medicine, The Sixth People's Hospital of Shenyang, Shenyang, China. ¹⁶ Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ¹⁷ Department of Gastroenterology, Air Force Hospital of Northern Theater Command, Shenyang, China. ¹⁸ Medicina Interna 1, Azienda di Rilievo Nazionale ad Alta Specializzazione Civico-Di Cristina-Benfratelli, Palermo, Italy. ¹⁹ Fourth Department of Liver Disease (Difficult & Complicated Liver Diseases and Artificial Liver Center), Beijing You'an Hospital Affiliated to Capital Medical University, Beijing, China. ²⁰ Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany. ²¹ Liver Research Center, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou 350000, Fujian, Chin. ²² Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. ²³ State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, No. 127 Changle West Road, Xi'an 710000, Shaanxi, China. ²⁴ Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, No. 17 Yongwai Zheng Street, Donghu District, Nanchang 330006, Jiangxi, China. ²⁵ Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of China Medical University), No. 83 Wenhua Road, Shenyang 110840, Liaoning Province, China.

刊名

Therapeutic advances in gastroenterology

年份

2025

卷号

Vol.18

页码

17562848241306934

ISSN

1756-283X

关键词

endoscopy failure to control bleeding liver cirrhosis thrombocytopenia variceal bleeding.

摘要

Background: Acute variceal bleeding , a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is a risk of early rebleeding after endoscopic variceal treatment . Thrombocytopenia is the most common hemostatic abnormality in liver cirrhosis. However, it is still unclear about whether thrombocytopenia increases the failure of EVT in cirrhotic patients with AVB. Objectives: We investigated the association between thrombocytopenia and the failure of EVT...更多

Background: Acute variceal bleeding , a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is a risk of early rebleeding after endoscopic variceal treatment . Thrombocytopenia is the most common hemostatic abnormality in liver cirrhosis. However, it is still unclear about whether thrombocytopenia increases the failure of EVT in cirrhotic patients with AVB. Objectives: We investigated the association between thrombocytopenia and the failure of EVT in cirrhotic patients with AVB. Design: International multicenter, retrospective study. Methods: Overall, 2467 cirrhotic patients with acute gastrointestinal bleeding who were enrolled into an international multicenter study between September 30, 2020 and June 30, 2023 were retrospectively screened. Thrombocytopenia was defined as platelet count below 150 × 10/L and further classified as mild , moderate , and severe . A 1:1 propensity score matching analysis was performed. Five-day failure to control bleeding was evaluated. Results: Overall, 1079 patients were included, of whom 923 had thrombocytopenia, including mild , moderate , and severe thrombocytopenia. PSM analysis demonstrated that the rate of 5-day failure to control bleeding was not significantly different between patients with and without thrombocytopenia 7.8% vs 4.6%, p = 0.236; moderate: 5.8% vs 4.5%, p = 0.608; or severe: 3.8% vs 5.3%, p = 0.555). Conclusion: Thrombocytopenia may not influence the efficacy of EVT in cirrhotic patients with AVB.收起

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