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作者

Xiaojuan Han, Yuanjing Li, Jiafeng Wang, Xinyu Liu, Yu Zhang, Qiwei Dong, Yiming Song, Lin Cong, Qinghua Zhang, Shi Tang, Lin Song, Tingting Hou, Yongxiang Wang, Yifeng Du, Chengxuan Qiu

作者单位

Affiliations ¹ Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China. ² Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China. ³ Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institute-Stockholm University, Stockholm, Sweden. ⁴ The Swedish School of Sport and Health Science, GIH, Stockholm, Sweden. ⁵ Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.

刊名

Journal of Alzheimer's disease : JAD

年份

2025

ISSN

1875-8908

关键词

Alzheimer's disease-related plasma biomarkers cognitive function cognitive reserve population-based study.

摘要

Background: Cognitive reserve , typically measured through socio-behavioral proxies, can partially explain better cognitive performance despite underlying brain aging or neuropathology. Objective: To examine the associations of CR with mild cognitive impairment and cognitive function while considering Alzheimer's disease -related plasma biomarkers. Methods: This population-based cross-sectional study included 4706 dementia-free individuals from MIND-China. Data on AD-related plasma biomarkers w...更多

Background: Cognitive reserve , typically measured through socio-behavioral proxies, can partially explain better cognitive performance despite underlying brain aging or neuropathology. Objective: To examine the associations of CR with mild cognitive impairment and cognitive function while considering Alzheimer's disease -related plasma biomarkers. Methods: This population-based cross-sectional study included 4706 dementia-free individuals from MIND-China. Data on AD-related plasma biomarkers were available for 1204 individuals. A composite CR score was generated by integrating education, occupational complexity, mental activity, and social support, using structural equation modeling. A neuropsychological test battery was used to assess the function of episodic memory, executive function, attention, and verbal fluency. MCI and subtypes of MCI were defined according to the Petersen's criteria. Data were analyzed using general linear and logistic regression models. Results: Controlling for AD-related plasma biomarkers, higher educational attainment was associated with better performance in all four examined cognitive domains . Higher composite CR scores were related to better performance in all the examined cognitive domains as well as lower likelihoods of MCI, aMCI, and non-aMCI . Conclusions: Greater composite CR, derived from the CR indicators across different stages of the lifespan, is associated with better cognitive function independent of AD-related plasma biomarkers, driven mainly by early-life educational attainment.收起

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