The effect of replacing sedentary behaviour with different intensities of physical activity on depression: A meta-analysis of isotemporal substitution studies
2Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, China1School of Nursing and Rehabilitation, Shandong University, Jinan 250000, China
刊名
Mental Health and Physical Activity
年份
2025
卷号
Vol.28
页码
100677
ISSN
1755-2966
摘要
Objective Physical activity, sedentary behaviour and sleep are modifiable risk factors associated with depressive symptoms, but there are conflicting findings regarding their relationship. Some studies reported that increased physical activity significantly reduces depressive symptoms, while others suggested that changes in sedentary behaviour or sleep have a more significant effect on depressive symptoms. In addition, many individual studies have ignored the dependencies between these behaviour...更多
Objective Physical activity, sedentary behaviour and sleep are modifiable risk factors associated with depressive symptoms, but there are conflicting findings regarding their relationship. Some studies reported that increased physical activity significantly reduces depressive symptoms, while others suggested that changes in sedentary behaviour or sleep have a more significant effect on depressive symptoms. In addition, many individual studies have ignored the dependencies between these behaviours. Studies have explored the effects of replacing sedentary behaviour with physical activity on depression, but the results remain inconclusive. Therefore, we aimed to summarize the evidence from studies that have used isotemporal substitution models to explore the effects of reallocating sedentary time to different activity intensities on adults with depression. Methods From inception to July 2024, a systematic search of Chinese and English databases was conducted to look for observational studies reporting the effects of replacing sedentary behaviours with light and/or moderate to vigorous physical activity, as well as sleep on depression. Random effects meta-analyses were performed to summarize the estimated odds ratios and regression coefficients and the corresponding 95 % confidence intervals . The OR reflects the effect of the substitution effect on the risk of depression, while the β reflects the effect on the level of depression. Subgroup analyses were also performed to explore potential moderators of heterogeneity. Study quality was assessed via the Newcastle-Ottawa Scale and the Agency for Health care Research and Quality evaluation criteria. Results Seventeen studies with 136,270 participants met the inclusion criteria. Pooled analyses revealed that replacing sedentary time with LPA was not significantly associated with depression in either cross-sectional or prospective cohort studies . Reallocating sedentary time to patients' self-reported duration of sleep was associated with a reduction in depression . An accelerometer was used to measure physical activity, and replacing sedentary time with MVPA was cross-sectionally associated with depression , but no longitudinal association was found. Conclusion Replacing sedentary behaviours with moderate to vigorous physical activity and sleep may reduce the odds ratio of depression, but more research is needed to demonstrate the role of light-intensity physical activity on depression. Exercise guidelines and effective strategies to prevent depression must be developed to integrate the interplay of activity behaviours and provide targeted recommendations for time reallocation.收起
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