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作者

Mikhail Kryuchkov, Zhehui Wang, Jana Valnohova, Vladimir Savitsky, Mirza Karamehmedović, Marc Jobin, Vladimir L Katanaev

作者单位

Rue de la Prairie, CH-1202 Geneva, Switzerland. Affiliations ¹ Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH-1211 Geneva, Switzerland. ² School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University (Shandong Academy of Medical Sciences), Tai'an 271016, China. ³ Zoological Museum, Moscow Lomonosov State University, Bol'shaya Nikitskaya Street 2, Moscow 125009, Russia. ⁴ Department of Applied Mathematics and Computer Science, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. ⁵ Haute ecole du Paysage, D'ingenierie et D'architecture de Geneve, University of Applied Sciences of Western Switzerland (HES-SO),

刊名

Biomimetics (Basel, Switzerland)

年份

2025

卷号

Vol.10 No.3

页码

163

ISSN

2313-7673

关键词

active coating antireflective bio-mimetic eco-friendly protein-based coatings self-assembly smart materials switchable.

摘要

Nanopatterning of signal-transmitting proteins is essential for cell physiology and drug delivery but faces challenges such as high cost, limited pattern variability, and non-biofriendly materials. Arthropods, particularly beetles , offer a natural model for biomimetic nanopatterning due to their diverse corneal nanostructures. Using atomic force microscopy , we analyzed Coleoptera corneal nanocoatings and identified dimpled nanostructures that can transform into maze-like/nipple-like protrusion...更多

Nanopatterning of signal-transmitting proteins is essential for cell physiology and drug delivery but faces challenges such as high cost, limited pattern variability, and non-biofriendly materials. Arthropods, particularly beetles , offer a natural model for biomimetic nanopatterning due to their diverse corneal nanostructures. Using atomic force microscopy , we analyzed Coleoptera corneal nanocoatings and identified dimpled nanostructures that can transform into maze-like/nipple-like protrusions. Further analysis suggested that these modifications result from a temporary, self-assembled process influenced by surface adhesion. We identified cuticular protein 7 as a key component of dimpled nanocoatings. Biophysical analysis revealed CP7's unique self-assembly properties, allowing us to replicate its nanopatterning ability in vitro. Our findings demonstrate CP7's potential for bioinspired nanocoatings and provide insights into the evolutionary mechanisms of nanostructure formation. This research paves the way for cost-effective, biomimetic nanopatterning strategies with applications in nanotechnology and biomedicine.收起

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