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作者

Zou, Yutong Wang, Yifei Ma, Xiaoli Mu, Danni Zhong, Jian Ma, Chaochao Mao, Chenhui Yu, Songlin Gao, Jing Qiu, Ling

作者单位

Chinese Academy of Medical Sciences, Beijing 100730, China ¹Department of Laboratory Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China ⁴State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China ²Department of Pathology and Lab Medicine, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan 250117, Shandong, China ³Department of Neurology, Peking Union Medical College &

刊名

Ageing Research Reviews

年份

2024

卷号

Vol.101

ISSN

1568-1637

关键词

Alzheimer's disease Blood Cerebrospinal fluid Diagnostic reviews Glial fibrillary acidic protein

摘要

Recently included in the 2024 new revised diagnostic criteria of Alzheimer's disease , glial fibrillary acidic protein has garnered significant attention. A systematic review and meta-analysis were performed to comprehensively evaluate the diagnostic, differential diagnostic, and prospective diagnostic performance of GFAP in cerebrospinal fluid and blood for AD continuum. A literature search using common electronic databases, important websites and historical search way was performed from ince...更多

Recently included in the 2024 new revised diagnostic criteria of Alzheimer's disease , glial fibrillary acidic protein has garnered significant attention. A systematic review and meta-analysis were performed to comprehensively evaluate the diagnostic, differential diagnostic, and prospective diagnostic performance of GFAP in cerebrospinal fluid and blood for AD continuum. A literature search using common electronic databases, important websites and historical search way was performed from inception to the beginning of March 2023. The inclusion criteria was studies evaluating the diagnostic accuracy of GFAP in CSF and/or blood for the AD continuum patients, utilizing PET scans, CSF biomarkers and/or clinical criteria. The systematic review and meta-analysis were conducted referring to the Cochrane Handbook. In total, 34 articles were eventually included in the meta-analysis, 29 of which were published within the past three years. Blood GFAP exhibited good diagnostic accuracy across various AD continuum patients, and the summary area under curve for distinguishing PET positive and negative individuals, CSF biomarkers defined positive and negative individuals, clinically diagnosed AD and cognitive unimpaired controls, AD and/or mild cognitive impairment and other neurological diseases, and prospective cases and controls was 0.85[0.81–0.88], 0.77[0.73–0.81], 0.92[0.90–0.94], 0.80[0.77–0.84], and 0.79[0.75–0.82], respectively. Only several studies were recognized to evaluate the diagnostic accuracy of CSF GFAP, which was not as good as that of blood GFAP , but its accuracy remarkably increased to AUC = 0.91 when combined with other factors like sex, age, and ApoE genotype. In summary, GFAP, particularly in blood, shown good diagnostic, differential diagnostic, and prospective diagnostic accuracy for AD continuum patients, with improved accuracy when used alongside other basic indexes. • First diagnostic meta-analysis of CSF and blood GFAP in the Alzheimer's disease continuum patients. • Both cross-sectional and prospective studies were included and analyzed. • GFAP alone shown good diagnostic accuracy for clinical/biomarker-defined AD patients. • Blood GFAP demonstrated superior diagnostic accuracy compared to CSF GFAP. • Combining basic indexes could enhance diagnostic accuracy, especially for CSF GFAP.收起

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