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作者

Song, Guohua Lin, Quanqiang Zhao, Hui Liu, Meiyuan Ye, Fenglong Sun, Yujuan Yu, Yang Guo, Shoudong Jiao, Peng Wu, Yun Ding, Guoyong Xiao, Qiang Qin, Shucun

作者单位

YingSheng East Road, ShanDong, 271000, China ^aKey Laboratory of Atherosclerosis in Universities of Shandong, Institute of Atherosclerosis, TaiShan Medical University, No. ^eDepartment of Cardiology, Affiliated Hospital of Taishan Medical University, Tai'an, 271000, China ^bHeart Center of TaiShan Medical University, Tai'an, 271000, China ^fInstitute of Public Health, TaiShan Medical University, Tai'an, 271000, China ^cZhoudian Community, Daiyue District, Tai'an, 271021, China ^dTai'An He Ren Tang Hospital, Tai'an, 271021, China

刊名

Journal of Clinical Endocrinology and Metabolism

年份

2015

卷号

Vol.100 No.7

页码

2724-2733

ISSN

0021-972X

摘要

Context: We have found that hydrogen decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in patients with potential metabolic syndrome in a before-after self-controlled study. Objective: The purpose of this study was to further characterize the effects ofH2-rich water on the content, composition, and biological activities of plasma lipoproteins on patients with hypercholesterolemia and their underlying mechanisms in a double-blinded, ran...更多

Context: We have found that hydrogen decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in patients with potential metabolic syndrome in a before-after self-controlled study. Objective: The purpose of this study was to further characterize the effects ofH2-rich water on the content, composition, and biological activities of plasma lipoproteins on patients with hypercholesterolemia and their underlying mechanisms in a double-blinded, randomized, and placebo-controlled trial. Design: This was a case-control study. Setting: The setting was the Zhoudian community, Tai'an, China. Patients: A total of 68 patients with untreated isolated hypercholesterolemia were randomly allocated to either drinking H2-rich water or placebo water for 10 weeks. Results: HDLisolated from theH2 groupshowedan increased ability to promote the ATP-binding cassette transporter A1-mediated cholesterol efflux ex vivo. Plasma pre-β-HDL levels were up-regulated although there were no changes in plasma HDL-cholesterol levels. Moreover, other HDL functions, assessed in protection against LDL oxidation, inhibition of oxidized-LDL-induced inflammation, and protection of endothelial cells from oxidized-LDL-induced apoptosis, were all significantly improved by H2 treatment. In addition, H2 treatment increased the effective rate in down-regulating plasma levels of total cholesterol and LDL cholesterol . Western blot analysis revealed a marked decrease in apolipoprotein B100 and an increase in apolipoproteinMin plasma of theH2 group. FinallyH2 treatment resulted in a significant reduction in the levels of several inflammatory and oxidative stress indicators in whole plasma and HDL particles. Conclusions: H2 activates ATP-binding cassette transporter A1-dependent efflux, enhances HDL antiatheroscleroticfunctions, andhasbeneficiallipid-loweringeffects.Thepresentfindingshighlightthepotential role of H2 in the regression of hypercholesterolemia and atherosclerosis.收起

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