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作者

刘保成 麻贞贞 白艳艳 刘 洁 杨清锐 刘东霞

作者单位

山东第一医科大学附属省立医院风湿免疫科，山东 济南

刊名

Advances in Clinical Medicine

年份

2024

卷号

Vol.14 No.2

页码

3723-3730

ISSN

2161-8712

关键词

干燥综合征 中枢神经系统损害 脊髓炎 Weber综合征 SjÖgren’s Syndrome Central Nervous System Damage Myelitis Weber Syndrome

摘要

Objective: To explore the clinical characteristics of Sjögren’s syndrome with central nervous system manifestations as the first symptom to guide diagnosis and timely treatment. Methods: The clinical characteristics, diagnosis and treatment of 3 patients with Sjögren’s syndrome with central nervous system damage as the first symptom were retrospectively analyzed, and literature analysis was conducted based on relevant domestic and foreign literature. Results: Two patients were middle-aged women ...更多

Objective: To explore the clinical characteristics of Sjögren’s syndrome with central nervous system manifestations as the first symptom to guide diagnosis and timely treatment. Methods: The clinical characteristics, diagnosis and treatment of 3 patients with Sjögren’s syndrome with central nervous system damage as the first symptom were retrospectively analyzed, and literature analysis was conducted based on relevant domestic and foreign literature. Results: Two patients were middle-aged women and one was a young man. The manifestations of central nervous system involvement include myelitis, Weber syndrome, brainstem lesions combined with cerebral infarc-tion and secondary epilepsy. Imaging manifestations are mostly high signal on cranial magnetic resonance imaging FLAIR and high signal on T2WI. All 3 patients were treated with high-dose glu-cocorticoids, combined with mycophenolate mofetil, cyclophosphamide, and immunoglobulin re-spectively. After treatment, the condition improved in two patients and worsened in one patient who ended up with death. Conclusion: For central nervous system damage that cannot be explained by other reasons, one should be alert to the possibility of primary Sjögren’s syndrome, regardless of age and gender, paying attention to medical history collection and laboratory index testing to make early diagnosis and timely treatment, to reduce the morbidity and mortality of the patients.收起

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