Antihypertensive Effects of SGLT-2 Inhibitors and Progress in Research

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作者单位: 山东第一医科大学(山东省医学科学院)研究生院，山东济南山东省济南市第三人民医院重症医学科，山东济南山东第一医科大学第一附属医院(山东省千佛山医院)保健心血管内科，山东济南

关键词: SGLT-2抑制剂高血压临床应用作用机制 Sodium-Glucose Transporter 2 Inhibitors Hypertension Clinical Application Pharmacology

摘要: Sodium-glucose transporter 2 inhibitors are a relatively new class of hypoglycemic agents that do not rely on stimulation of insulin secretion to lower blood glucose via urinary glucose, and a large body of evidence suggests that they have outstanding cardiovascular applications. With a large population base, hypertension is not only a comorbidity of many diseases, but also a risk fac-tor for many diseases and affects the prognosis. With the deeper understanding of SGLT-2i and the summary of re...更多; Sodium-glucose transporter 2 inhibitors are a relatively new class of hypoglycemic agents that do not rely on stimulation of insulin secretion to lower blood glucose via urinary glucose, and a large body of evidence suggests that they have outstanding cardiovascular applications. With a large population base, hypertension is not only a comorbidity of many diseases, but also a risk fac-tor for many diseases and affects the prognosis. With the deeper understanding of SGLT-2i and the summary of results from clinical trials in subjects, the antihypertensive effect has come under scru-tiny, highlighting the potential value and multiplicity of the drug beyond glucose lowering alone. The evidence for antihypertensive effects and possible antihypertensive mechanisms in the clinical application of SGLT-2i are reviewed.收起

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