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作者

Qian-Qian Xu Ke-Xin Zheng Yuan-Yuan Cui Cheng-Xiong Yang

作者单位

¹School of Pharmaceutical Sciences & Institute of Materia Medica, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China

刊名

ACS Applied Nano Materials

年份

2025

卷号

Vol.8 No.15

页码

7482-7490

关键词

microporous organic network salvianolic acid B phenylboronic acid adsorption complex samples

摘要

Selective enrichment and isolation of polar phenolic acid compounds from the complex matrix of traditional Chinese medicine Salvia miltiorrhiza is challenging yet highly desirable due to their excellent pharmacological activities on cardiovascular and cerebrovascular systems. However, owing to their polar and ionic characteristics, trace levels of phenolic acid compounds, and the complexity of traditional Chinese medicine matrices, the selectivity and adsorption capacity of conventional separat...更多

Selective enrichment and isolation of polar phenolic acid compounds from the complex matrix of traditional Chinese medicine Salvia miltiorrhiza is challenging yet highly desirable due to their excellent pharmacological activities on cardiovascular and cerebrovascular systems. However, owing to their polar and ionic characteristics, trace levels of phenolic acid compounds, and the complexity of traditional Chinese medicine matrices, the selectivity and adsorption capacity of conventional separation media remain limited. Therefore, the rational design of efficient and selective extractants is crucial. In this study, a phenylboronic acid-functionalized microporous organic network , with nanoscale porosity and a high surface area , was synthesized and employed as an adsorbent for the selective and efficient enrichment of the phenolic acid compound salvianolic acid B from Salvia miltiorrhiza. A monomer containing phenylboronic acid groups was chosen to construct p-PBA-MON, forming specific five- or six-membered cyclic esters with cis-diol groups in SAB and providing synergistic π–π and hydrogen bonding sites. This results in the selective adsorption of SAB with ultrafast adsorption kinetics and high adsorption capacity . The synthesized p-PBA-MON tolerates the influences of ionic strength and humic acid and can be reused at least five times without a decrease in adsorption capacity. This study introduces an efficient adsorbent for the selective enrichment and separation of polar SAB from complex traditional Chinese medicine samples. This advancement could significantly extend the application of MON in the extraction and purification of active substances from Chinese medicine and promote its development in the separation of complex samples.收起

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期刊