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作者

Xiao Lin Haochen Liu Yan Liu Qinghua Li Fan Wu Ju Zhang Changxiang Song Shunyao Jin Qisheng Liu Wenlong Li Qingdong Bao

作者单位

⁶School of Ophthalmology, Shandong First Medical University, Jinan, 250001, China ²Xiao Lin and Haochen Liu contributed equally to this work. ⁵State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Qingdao, 266071, China ³Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200000, China ⁴Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, 250021, China ¹Medical School of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, 250001, China

刊名

Progress in Organic Coatings

年份

2026

卷号

Vol.210

页码

109687

ISSN

0300-9440

摘要

Myopia has become a primary cause of irreversible blindness and visual impairment, with its prevalence continuing to rise globally. Orthokeratology lenses are highly effective in managing myopia progression; however, they are prone to promoting tear protein adhesion and bacterial infections during use, which compromises their safety and efficacy. This study aimed to establish a novel surface modification technique to enhance the antifouling and antibacterial properties of OK lenses through the ...更多

Myopia has become a primary cause of irreversible blindness and visual impairment, with its prevalence continuing to rise globally. Orthokeratology lenses are highly effective in managing myopia progression; however, they are prone to promoting tear protein adhesion and bacterial infections during use, which compromises their safety and efficacy. This study aimed to establish a novel surface modification technique to enhance the antifouling and antibacterial properties of OK lenses through the commodification of aminophenylboronic acid -incorporated poly and poly-l-lysine brushes mediated by a polydopamine coating. Taking advantage of the pH-responsive property of the PMAA brushes, the designed coating could intelligently switch biofunctions from antifouling to antibacterial on demand. PMAA brushes can form a dense hydration layer on a material surface, effectively resist protein adhesion, and demonstrate good biocompatibility under physiological conditions. Upon encountering bacterial adhesion, the outstretched brushes would collapse, exposing the PLL, which would immediately kill the contacted bacteria. When numerous bacteria adhere to the surface, the acidic environment leads to the breakage of Schiff base bonds,. resulting in the release of PLL and the responsive killing of bacteria. Resulting in the release of PLL and the responsive killing of bacteria. The near-infrared light-responsive layer of PDA can effectively enhance the bactericidal effects of the coating under NIR irradiation. The OK-PDA-PMAA-PLL-NBA lens is excellent for bacterial sterilization and resists protein adhesion, demonstrating excellent biocompatibility and leading to fewer complications, thus providing an innovative and promising approach for combating myopia.收起

文献类型

期刊