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作者

Wenqi Wu, Zhibin Wang, Lina Ding, Yikun Zhang, Kaihui Ma, Hongsheng Li, Yanli Hou, Wenyu Ding

作者单位

com. ⁸ Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250062, China. 18553135697@16 com. ¹⁰ Jinan Key Laboratory of Translational Medicine On Metabolic Diseases, Jinan, 250062, China. 18553135697@16 com. ⁶ Shandong Institute of Endocrine and Metabolic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250062, China. houyanlixy@16 Affiliations ¹ Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250062, China. ² Shandong Institute of Endocrine and Metabolic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250062, China. ³ Jinan Key Laboratory of Translational Medicine On Metabolic Diseases, Jinan, 250062, China. ⁴ Shandong First Medical University, Jinan, 250018, China. ⁵ Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250062, China. houyanlixy@16 com. ⁹ Shandong Institute of Endocrine and Metabolic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250062, China. 18553135697@16 com. com. ⁷ Jinan Key Laboratory of Translational Medicine On Metabolic Diseases, Jinan, 250062, China. houyanlixy@16

刊名

Probiotics and antimicrobial proteins

年份

2025

ISSN

1867-1314

关键词

Gut microbiota Inflammation Lactiplantibacillus plantarum Type 2 diabetes mellitus.

摘要

This review investigates the mechanisms, functional roles, and therapeutic potential of Lactiplantibacillus plantarum in type 2 diabetes mellitus and its associated metabolic disorders. As a widely recognized probiotic species due to its widespread use in food processing and as a natural inhabitant of human and animal gastrointestinal tracts, Lactiplantibacillus plantarum has garnered significant attention for its potential in metabolic regulation. Specifically, this study focuses on its capac...更多

This review investigates the mechanisms, functional roles, and therapeutic potential of Lactiplantibacillus plantarum in type 2 diabetes mellitus and its associated metabolic disorders. As a widely recognized probiotic species due to its widespread use in food processing and as a natural inhabitant of human and animal gastrointestinal tracts, Lactiplantibacillus plantarum has garnered significant attention for its potential in metabolic regulation. Specifically, this study focuses on its capacities to alleviate insulin resistance, restore insulin secretion, and ameliorate dyslipidemia, among other metabolic disturbances. The mechanisms underlying Lactiplantibacillus plantarum's beneficial effects on lipid and glucose metabolism are multifactorial, including modulation of gut microbiota composition, restoration of intestinal barrier function, mitigation of systemic inflammation, and potentiation of metabolic regulatory pathways. Notably, Lactiplantibacillus plantarum achieves these effects by regulating glycolytic and lipid biosynthesis, modulating intestinal hormone signaling, and influencing cholesterol and fatty acid metabolism. These findings underscore the potential of Lactiplantibacillus plantarum as a probiotic agent in the treatment of T2DM and related disorders. However, to fully harness its therapeutic potential, further studies are required to validate its safety and efficacy in diverse clinical settings.收起

文献类型

期刊