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作者

Shangcheng Yu, Zhiqiang Li, Yuxiang Tang, Yuling Chen, Yingying Ma, Kunlin Du, Zhaoyun Zong, Kangze Feng, Yali Wei, Limeng Chen, Haiteng Deng

作者单位

Affiliations ¹ MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China. ² Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. ³ Department of Nephrology, Peking Union Medical College Hospital, Beijing, China. ⁴ Zhejiang Key Laboratory of Multiomics and Molecular Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, China.

刊名

Aging cell

年份

2025

卷号

Vol.24 No.9

页码

e70147

ISSN

1474-9726

关键词

CD38 aging peptide vaccine.

摘要

Antiaging vaccines have recently been found to elicit long-term benefits in slowing the aging process. Meanwhile, high CD38 expression in organs is an aging characteristic contributing to a decreased NAD/NADH ratio. Thus, in the current study, we systematically investigate the effects of a CD38-targeting peptide vaccine on aging-associated phenotypes in mice. The CD38-vaccine induces a robust T-cell immune response, selectively depletes CD38 myeloid cells in the spleen, and ameliorates age-rela...更多

Antiaging vaccines have recently been found to elicit long-term benefits in slowing the aging process. Meanwhile, high CD38 expression in organs is an aging characteristic contributing to a decreased NAD/NADH ratio. Thus, in the current study, we systematically investigate the effects of a CD38-targeting peptide vaccine on aging-associated phenotypes in mice. The CD38-vaccine induces a robust T-cell immune response, selectively depletes CD38 myeloid cells in the spleen, and ameliorates age-related physical and cognitive function decline. Metabolically, vaccination improves glucose tolerance, enhances oxygen consumption, and decreases the number of senescent cells and mRNA levels of senescence-related genes in liver tissues. Vaccination also increases the NAD/NADH ratio in the liver tissues, enhances oxidative metabolism, and reduces glycolysis. These findings indicate that targeting CD38 via vaccination is a promising strategy for ameliorating aging-associated phenotypes.收起

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