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作者

Qizhao Li, Shuai Wang, Wenjuan Gao, Yuying Wei, Xiao Gao, Puzhou Wang, Johan Rebetz, Elisabeth Semple, Li Guo, John W Semple, Joaquín Martínez-López, Jun Peng, Shuqian Xu

作者单位

Division of Hematology and Oncology, University of Washington, Seattle, WA, USA Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. ⁵ Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden Affiliations ¹ Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China. ² Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. ³ Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden. ⁴ Bloodworks Northwest Research Institute, Seattle, WA, USA Departments of Pharmacology, Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. ⁶ Hospital 12 de Octubre, i+12, CNIO, Complutense University, Madrid, Spain. ⁷ Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China. Electronic address: shuqian.xu@email.sdu.edu.cn. Clinical Immunology and Transfusion Medicine, Office of Medical Services, Region Skåne, Lund, Sweden

刊名

Experimental gerontology

年份

2025

卷号

Vol.211

页码

112916

ISSN

1873-6815

关键词

Anemia Aplastic anemia Iron-deficiency anemia Mendelian randomization NHANES Risk factor Stroke The middle-aged and the elderly.

摘要

Stroke and anemia are both prevalent conditions with significant health burdens, yet their bidirectional relationship remains poorly understood. Anemia affects up to 29 % of stroke patients and is associated with increased worse outcomes. However, the causal nature of this association, particularly concerning different anemia subtypes, remains controversial, and there is a lack of clear targets and specific treatments for anemia in stroke patients. This study employed data from National Health a...更多

Stroke and anemia are both prevalent conditions with significant health burdens, yet their bidirectional relationship remains poorly understood. Anemia affects up to 29 % of stroke patients and is associated with increased worse outcomes. However, the causal nature of this association, particularly concerning different anemia subtypes, remains controversial, and there is a lack of clear targets and specific treatments for anemia in stroke patients. This study employed data from National Health and Nutrition Examination Survey database and two sample Mendelian randomization to investigate the relationship between different types of anemia, particularly aplastic anemia and iron deficiency anemia , and the risk of stroke and its subtypes in adults. The study included 7931 participants from NHANES . After adjusting for all covariates, the exposure factor of stroke was significantly positively correlated with the risk of anemia in middle-aged and elderly females, while in males, although the correlation was not significant, it was close to the threshold . Genetically instrumented total anemia risk was nominally associated with risk of stroke , IDA and AA were significantly associated with stroke risk. Furthermore, both genetic instrumented IDA and AA were significantly associated with an increased risk of large artery stroke but not with other stroke subtypes, in a unidirectional manner. The reverse MR analyses showed that genetically predicted stroke risk also associated with increased risk of total anemia , as well as with subtypes of anemia . In conclusion, a bidirectional association between increased risk of two types of anemia and elevated stroke risk was observed, with varying magnitudes of effect. Randomized trials are now needed to assess the effects of different treatments for anemia on stroke and its subtypes, particularly in high-risk older individuals.收起

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