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作者

Qingtong Wang Ziqun Wang Chuanzheng Wang Huihan Tian Yanhua Qi Xin Yan Rongrong Zhao Boyan Li Caizhi Ma Tao Xin Jianquan Yao Haiyun Yao Hao Xue Lanju Liang Gang Li

作者单位

⁴Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P. R. China Bei’an Road, Zaozhuang City, Shandong Province, Zaozhuang, Shandong 277160, China ²Shandong Key Laboratory of Brain Health and Functional Remodeling, Jinan 250012 Shandong, China ¹Department of Neurosurgery, Qilu Hospital of Shandong University, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, 250012 Shandong, China ⁵College of Precision Instruments and Optoelectronics Engineering, Tianjin University, No.92 Weijin Road, Tianjin 300072, China ³School of Optoelectronic Engineering, Zaozhuang University, No

刊名

ACS Sensors

年份

2025

卷号

Vol.10 No.10

页码

7549-7558

关键词

slope extrusion microchannel postoperative central nervous system infections cerebrospinal fluid THz metasurface biosensor

摘要

Postoperative central nervous system infections are serious complications following craniotomy, for which prompt diagnosis and empirical antimicrobial treatment are critical to reducing comorbid complications and mortality. Clinically, PCNSIs and their severity are determined by the leukocyte concentration and multinucleated cell/monocyte ratio in cerebrospinal fluid . However, traditional detection methods are time-consuming and unsuitable for rapid bedside use. Here, we propose a novel tera...更多

Postoperative central nervous system infections are serious complications following craniotomy, for which prompt diagnosis and empirical antimicrobial treatment are critical to reducing comorbid complications and mortality. Clinically, PCNSIs and their severity are determined by the leukocyte concentration and multinucleated cell/monocyte ratio in cerebrospinal fluid . However, traditional detection methods are time-consuming and unsuitable for rapid bedside use. Here, we propose a novel terahertz biosensor that integrates a metasurface with slope lateral extrusion technology, which shows a significant response to leukocytes in CSF while having minimal impact on other components, such as erythrocytes and proteins. This innovative sensor enables precise, rapid, and label-free detection of both L and MNC/MO ratio in complex liquid environments. Specifically, it can simultaneously quantify the L across a broad range and the MNC/MO ratio by monitoring changes in resonance frequency and transmission intensity. Mechanistically, monocytes induce more pronounced changes in frequency and transmission intensity compared to multinucleated cells, a difference attributed to variations in dielectric constant caused by disparities in cell volume and nuclear-to-cytoplasmic ratio. This innovative approach achieves, for the first time, accurate detection of components in complex body fluids. Validation using clinical CSF samples demonstrates its potential for reliable quantitative analysis, highlighting its significance for rapid bedside diagnosis and their severity of PCNSIs.收起

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