Research progress on the biological activity of marine-derive 1,6-naphthyridine nature products

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作者单位: ^cShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China ^bShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, 264117, China ^aShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China

关键词: 1 6-naphthyridine Biological activity Marine natural product Mechanism of action

摘要: At present, all known marine-derived 1,6-naphthyridine natural products have been isolated from sponge organisms. Research indicates that these compounds exhibit significant biological activities in various fields, including antitumor, antioxidant, and antibacterial properties, demonstrating broad potential for drug development. This article systematically reviews the sources, chemical structures, biological activities, and mechanisms of action of 42 marine-derived 1, 6-naphthyridine natural pro...更多; At present, all known marine-derived 1,6-naphthyridine natural products have been isolated from sponge organisms. Research indicates that these compounds exhibit significant biological activities in various fields, including antitumor, antioxidant, and antibacterial properties, demonstrating broad potential for drug development. This article systematically reviews the sources, chemical structures, biological activities, and mechanisms of action of 42 marine-derived 1, 6-naphthyridine natural products. This study aims to systematically summarize the biological activities of these natural products, thereby identifying novel structures and prominent active compounds as potential leads for new drug development. At the same time, these studies lay the foundation for the development of highly effective and low-toxicity new drugs, thereby making an important contribution to human health.收起

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