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作者

Ying Yan Zheng Wang Wei Wei Zhenghan Yang Lingfei Guo Zhenchang Wang Xuan Wei

作者单位

Department of Radiology，Beijing Friendship Hospital，Capital Medical University，Beijing，China；Department of Radiology，Beijing Friendship Hospital，Capital Medical University，Beijing，China；Division of Science and Technology，Beijing Friendship Hospital，Capital Medical University，Beijing，China；Department of Radiology，Beijing Friendship Hospital，Capital Medical University，Beijing，China；Department of Radiology，Shandong Provincial Hospital Affiliated to Shandong First Medical University，Jinan，China；Department of Radiology，Beijing Friendship Hospital，Capital Medical University，Beijing，China；Department of Radiology，Beijing Friendship Hospital，Capital Medical University，Beijing，China

刊名

定量影像学

年份

2023

卷号

第13卷

期号

第12期

页码

7961-7972

关键词

Quantitative susceptibility mapping (QSM) magnetic resonance imaging (MRI) Parkinson’s disease (PD) freezing of gait (FOG) iron deposition

摘要

BackgroundQuantitative susceptibility mapping is a novel imaging method for detecting iron content in the brain. The study aimed determine whether the iron deposition in the brains of people with Parkinson’s disease is correlated with freezing of gait .MethodsWe retrospectively collected the data of 24 patients with PD from the Movement Disorders Program and 36 healthy controls from January 2021 to December 2021. Clinical assessments included mental intelligence scales, Parkinson rating scale...更多

BackgroundQuantitative susceptibility mapping is a novel imaging method for detecting iron content in the brain. The study aimed determine whether the iron deposition in the brains of people with Parkinson’s disease is correlated with freezing of gait .MethodsWe retrospectively collected the data of 24 patients with PD from the Movement Disorders Program and 36 healthy controls from January 2021 to December 2021. Clinical assessments included mental intelligence scales, Parkinson rating scales, motor-related scales, and clinical gait assessments. All exercise scales and gait assessments were performed in the “ON” and “OFF” states. Magnetic resonance imaging data were collected using 3-dimensional fast low-angle shot sequences. We chose the bilateral red nucleus, substantia nigra, thalamus, putamen, caudate nucleus, and globus pallidus as regions of interest for QSM analysis.ResultsThe iron deposition in the substantia nigra of the PD group was significantly higher than that of the HC group . In the PD group, the iron deposition in the substantia nigra of patients with FOG was significantly higher than that in patients without FOG . The iron deposition in the substantia nigra was positively correlated with the New Freezing of Gait Questionnaire . The scores for depression and anxiety of the PD group were significantly higher than those of the HC group, while the Berg balance scale score was significantly lower .ConclusionsThe iron deposition in the substantia nigra of patients with PD is increased compared with that of controls and is associated with FOG. QSM can be used to detect brain iron deposition in patients with PD, which would help to explore the mechanism of abnormal neurobiological activity in FOG.收起

基金

国家自然科学基金

文献类型

期刊