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作者

Jie Cheng, Peng Wang, Long-Hao Liu, Qiu-Ting Zhang, Hong-Rui Yang, Xu Zhang, Ya-Min Hou, Yuan-Qing Lv, Ze-Ying Wang, Bin Liu, Tao Zhang, Ming-Xiang Zhang

作者单位

com. ³ Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, China. Electronic address: zhangtao_qdzt@12 National Key Laboratory for Innovation and Transformation of Luobing Theory, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. ² Department of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China. Electronic address: liubin409@16 National Key Laboratory for Innovation and Transformation of Luobing Theory, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. Electronic address: zhangmingxiang@sdu.edu.cn. Affiliations ¹ The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China com. ⁴ The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China

刊名

Journal of affective disorders

年份

2025

页码

120645

ISSN

1573-2517

关键词

Atherogenic index of plasma Cross-sectional study Depression Diabetes mellitus NHANES.

摘要

Background: Previous studies have demonstrated a strong correlation between the atherogenic index of plasma and both diabetes and depression. However, the relationship between AIP and the risk of depression in individuals with diabetes remains unclear. This study aimed to examine the association between AIP and the risk of depression in patients with diabetes. Methods: The data were derived from the National Health and Nutrition Examination Survey, a nationally representative cross-sectional da...更多

Background: Previous studies have demonstrated a strong correlation between the atherogenic index of plasma and both diabetes and depression. However, the relationship between AIP and the risk of depression in individuals with diabetes remains unclear. This study aimed to examine the association between AIP and the risk of depression in patients with diabetes. Methods: The data were derived from the National Health and Nutrition Examination Survey, a nationally representative cross-sectional database, from 2011 to 2018. Depression was assessed using the Patient Health Questionnaire-9. Weighted multivariate logistic regression models and restricted cubic spline regression were employed to evaluate the association between AIP and depression in patients with diabetes. Results: A total of 1773 participants with diabetes were included in the study, of whom 215 suffered from depression. The AIP was 0.41 ± 0.33. A multivariate logistic regression analysis showed a significant positive association between AIP and the risk of depression in patients with diabetes mellitus . Furthermore, a significant association was observed between sex and diabetes status; men with diabetes exhibited higher levels of AIP and an elevated risk of depression compared with women . Conclusions: Elevated AIP was significantly associated with an increased risk of depression in patients with diabetes, particularly among men. The integration of AIP measurement into routine metabolic monitoring has the potential to facilitate the early identification of individuals at high risk of depression.收起

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