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作者

Haixia Shen Shuaiguang Li Liyuan Lin Qian Wu Zhonghua Dong Wei Xu

作者单位

School of Pharmacy，The Shandong Second Medical University，Weifang，Shandong，261053，China；Department of Clinical Pharmacy，The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital，Jinan，250014，China；Department of Oncology，The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital，Shandong Lung Cancer Institute，Jinan，250014，China；School of Pharmacy，The Shandong Second Medical University，Weifang，Shandong，261053，China；Department of Clinical Pharmacy，The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital，Jinan，250014，China

刊名

药物分析学报(英文版)

年份

2025

卷号

第15卷

期号

第12期

页码

2749-2763

关键词

Plant-derived exosomes Delivery of drugs Extracellular vesicles Nanocarriers Nanoparticles

摘要

Exosomes,small vesicles secreted by a wide range of cells,are found extensively in animals,plants,and microorganisms.Their excellent biocompatibility,efficient delivery capacity,and ease of membrane crossing have drawn significant interest as promising drug delivery carriers.Compared with their animal-derived counterparts,plant-derived exosomes,in particular,stand out for their lower toxicity to human tissues,diverse sources,and enhanced targeted delivery capabilities.Advances in both in-depth r...更多

Exosomes,small vesicles secreted by a wide range of cells,are found extensively in animals,plants,and microorganisms.Their excellent biocompatibility,efficient delivery capacity,and ease of membrane crossing have drawn significant interest as promising drug delivery carriers.Compared with their animal-derived counterparts,plant-derived exosomes,in particular,stand out for their lower toxicity to human tissues,diverse sources,and enhanced targeted delivery capabilities.Advances in both in-depth research and technological development have enabled scholars to isolate exosomes successfully from various plants,exploring their potential in clinical therapies.However,the precise identification of PDEs and their drug delivery mechanisms remains an area of ongoing investigation.This review syn-thesizes the latest developments in the biogenesis,extraction,separation,and identification of PDEs,along with their engineering modifications and drug-loading strategies.We also delve into the thera-peutic applications of exosomes and their future potential in drug delivery,aiming to elucidate the targeted delivery mechanisms of PDEs and pave new paths for clinical drug treatment.收起

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