Against the backdrop of a rapidly aging population and the increasing global burden of dementia, early intervention targeting modifiable risk factors, particularly central obesity, has become critically important. The lipid accumulation product index, an emerging composite indicator that reflects visceral adipose tissue accumulation and lipid metabolism, has shown promise as a simple tool for dementia risk screening in community settings. This review aims to summarize current advances in LAP-re...更多
Against the backdrop of a rapidly aging population and the increasing global burden of dementia, early intervention targeting modifiable risk factors, particularly central obesity, has become critically important. The lipid accumulation product index, an emerging composite indicator that reflects visceral adipose tissue accumulation and lipid metabolism, has shown promise as a simple tool for dementia risk screening in community settings. This review aims to summarize current advances in LAP-related research and to elucidate the underlying mechanisms involving chronic inflammation and insulin resistance through which LAP may influence cognitive function, thereby providing insights for early prevention and intervention strategies for dementia.收起
