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作者

Wang, Xin Li, Han Wang, Ting Cui, Yuan-Yuan Yang, Cheng-Xiong

作者单位

^aSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University, Jinan, 250117, China

刊名

Journal of Instrumental Analysis

年份

2026

卷号

Vol.45 No.2

页码

274-281

ISSN

1004-4957

关键词

Crown ether High-performance liquid chromatography Microporous organic network Stationary phase

摘要

This work reports the first preparation of a crown ether-based microporous organic network coated silica gelcomposite stationary phase for high-performance liquid chromatog- raphy. Multiple characterization techniques confirm that the prepared CE-MONQSiO exhibits a large specific surface area and superhydrophobicity. In reverse-phase mode, the CE-MON@SiO packed column demonstrates high-efficiency separation of various analytes, including alkylbenzenes, polycyclic aromatic hydrocarbons, phenols, ...更多

This work reports the first preparation of a crown ether-based microporous organic network coated silica gelcomposite stationary phase for high-performance liquid chromatog- raphy. Multiple characterization techniques confirm that the prepared CE-MONQSiO exhibits a large specific surface area and superhydrophobicity. In reverse-phase mode, the CE-MON@SiO packed column demonstrates high-efficiency separation of various analytes, including alkylbenzenes, polycyclic aromatic hydrocarbons, phenols, anilines,  benzenediol isomers, halogenated aromatics, and phenylurea herbicides. Additionally, this column demonstrates excellent analytical reproducibility, with relative standard deviations of retention time not more than 1.3% across five consecutive injections. The CE-MON@SiO column demonstrates excellent reversed-phase chromatographic separation performance and potential hydrophilic interaction separation capabilities. It was found that the column may operate through multiple chromatographic interaction mechanisms such as hydrophobic interactions , π-π interactions, and host-guest interactions. These findings reveal that the CE-MON@SiO stationary phase exhibits great potential in the separation and analysis of complex aromatic compounds and pharmaceutical molecules.收起

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