Exosomes: critical mediator and therapeutic target for osteoarthritis

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作者: Peng Jiang, Jie Liu, Huiying Li, Huarong Shao, Haining Tan, Fei Liu, Peixue Ling, Qiuju Han, Xixi Dou

作者单位: Affiliations ¹ Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan, Shandong, China. ² Postdoctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Science Ji'nan, Shandong, China. ³ Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University Ji'nan, Shandong, China. ⁴ Shandong Provincial Key Laboratory of Carbohydrate and Glycoconjugate Drugs, Shandong Freda Pharmaceutical Group Co., Ltd Ji'nan, Shandong, China. ⁵ College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University Beijing, China.

摘要: Osteoarthritis is characterized by articular cartilage degradation and chondrocyte injury. Increased cell apoptosis of chondrocytes and inflammation are features of degenerating cartilage. Recently, exosomes are considered as important mediators of the pathogenesis and progression of OA. Importantly, exosomes originating from different cells, especially mesenchymal stem cells , have been shown to delay the progression of OA by different mechanisms. These exosomes derived from MSC harbor several...更多; Osteoarthritis is characterized by articular cartilage degradation and chondrocyte injury. Increased cell apoptosis of chondrocytes and inflammation are features of degenerating cartilage. Recently, exosomes are considered as important mediators of the pathogenesis and progression of OA. Importantly, exosomes originating from different cells, especially mesenchymal stem cells , have been shown to delay the progression of OA by different mechanisms. These exosomes derived from MSC harbor several proteins, lipids, nucleic acids, and cytosolic material that promote chondrocyte proliferation and migration and prevent the apoptosis of chondrocytes. Based on these findings, exosomes may serve be diagnostic biomarkers and therapeutic targets for OA. In this review, we summarize the role of exosomes and their key components in mediating OA development and therapy.收起

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