Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults

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作者: Zhen-Zhen Zhang Ping Wang Xiang-Lei Kong Wen-Li Mao Mei-Yu Cui

作者单位: Taishan Medical University；Department of Nephrology

刊名: 慢性疾病与转化医学(英文版)

年份: 2019

卷号: 第2期

页码: 122-128

ISSN: 2095-882X

关键词: HEMOGLOBIN Pulse wave velocity ARTERIAL STIFFNESS CARDIOVASCULAR diseases

分类号: R

摘要: Objective: Increased hemoglobin levels are known to be associated with increased cardiovascular events and mortalities. Therefore, we assumed that high Hb levels were associated with arterial stiffness. Pulse wave velocity is a simple and noninvasive method for measuring arterial stiffness to assess cardiovascular disease in general populations. Accordingly, we conducted a cross-sectional study to explore the association of Hb with PWV. Methods: A total of 6642 adults aged 54.5 ± 11.2 years un...更多; Objective: Increased hemoglobin levels are known to be associated with increased cardiovascular events and mortalities. Therefore, we assumed that high Hb levels were associated with arterial stiffness. Pulse wave velocity is a simple and noninvasive method for measuring arterial stiffness to assess cardiovascular disease in general populations. Accordingly, we conducted a cross-sectional study to explore the association of Hb with PWV. Methods: A total of 6642 adults aged 54.5 ± 11.2 years undergoing physical examinations were enrolled, 71.7% of whom were males. Arterial stiffness was evaluated by carotid-femoral PWV . Multivariable regression analyses were performed to determine the relationship between Hb and increased cfPWV. Results: In this study, the mean Hb was 144.7 ± 13.9 g/L, and the mean cfPWV was 15.1 ± 3.1 m/s. cfPWV was significantly higher in high hemoglobin groups >15.4 g/L than in the lowest hemoglobin group . Multiple linear regression analysis revealed that Hb positively correlated with cfPWV . Univariate Logistic regression analysis revealed that Hb was associated with increased cfPWV, with an odd ratio of 1.46 . After adjusting for potential confounders, Hb and the highest Hb quartile group were also independently associated with increased cfPWV, with a fully adjusted OR of 1.11 and 1.45 , respectively. Conclusion: This study demonstrated that Hb levels significantly correlate with increased cfPWV收起

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[1] Zhen-Zhen Zhang;Ping Wang;Xiang-Lei Kong;Wen-Li Mao;Mei-Yu Cui . Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults[J] 慢性疾病与转化医学(英文) 2019 . 第5卷第2期 . 122-128 .