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作者

Zhen-Zhen Zhang Ping Wang Xiang-Lei Kong Wen-Li Mao Mei-Yu Cui

作者单位

Taishan Medical University，Tai'an，Shandong 271000，China；Department of Nephrology，Qianfoshan Hospital Affiliated to Shandong University，Jinan，Shandong 250014，China；Department of Nephrology，Qianfoshan Hospital Affiliated to Shandong University，Jinan，Shandong 250014，China

刊名

慢性疾病与转化医学(英文)

年份

2019

卷号

第5卷

期号

第2期

页码

122-128

ISSN

2095-882X

关键词

Hemoglobin Pulse wave velocity Arterial stiffness Cardiovascular diseases

摘要

Objective:Increased hemoglobin levels are known to be associated with increased cardiovascular events and mortalities.Therefore,we assumed that high Hb levels were associated with arterial stiffness.Pulse wave velocity is a simple and noninvasive method for measuring arterial stiffness to assess cardiovascular disease in general populations.Accordingly,we conducted a cross-sectional study to explore the association of Hb with PWV.Methods:A total of 6642 adults aged 54.5 ± 11.2 years undergoing...更多

Objective:Increased hemoglobin levels are known to be associated with increased cardiovascular events and mortalities.Therefore,we assumed that high Hb levels were associated with arterial stiffness.Pulse wave velocity is a simple and noninvasive method for measuring arterial stiffness to assess cardiovascular disease in general populations.Accordingly,we conducted a cross-sectional study to explore the association of Hb with PWV.Methods:A total of 6642 adults aged 54.5 ± 11.2 years undergoing physical examinations were enrolled,71.7％ of whom were males.Arterial stiffness was evaluated by carotid-femoral PWV .Multivariable regression analyses were performed to determine the relationship between Hb and increased cfPWV.Results:In this study,the mean Hb was 144.7 ± 13.9 g/L,and the mean cfPWV was 15.1 ± 3.1 m/s.cfPWV was significantly higher in high hemoglobin groups ≥15.4 g/L than in the lowest hemoglobin group .Multiple linear regression analysis revealed that Hb positively correlated with cfPWV .Univariate Logistic regression analysis revealed that Hb was associated with increased cfPWV,with an odd ratio of 1.46 .After adjusting for potential confounders,Hb and the highest Hb quartile group were also independently associated with increased cfPWV,with a fully adjusted OR of 1.11 and 1.45 ,respectively.Conclusion:This study demonstrated that Hb levels significantly correlate with increased cfPWV.收起

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