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作者

Qu, Bao-Ge Wang, Hui Jia, Yi-Guo Su, Ji-Liang Wang, Zhong-Dong Wang, Ya-Fei Han, Xing-Hai Liu, Yuan-Xun Pan, Jin-Dun Ren, Guang-Ying

作者单位

From the Department of Gastroenterology (BQ, HW, YJ, JS, ZW, YW, XH, YL, JP, GR), Taishan Hospital, Taian, Shandong, and Taishan Medical College, Taian, Shandong, P.R. China.

刊名

Medicine (MEDICINE)

年份

2015

卷号

Vol.94 No.12

页码

e643

ISSN

0025-7974

摘要

The relationships among inflammation, oxidative balance, and the severity of alcoholic fatty liver disease remain unknown. The aim of this study is to explore the relationships among tumor necrosis factor alpha , heat shock protein 70 , malondialdehyde , superoxide dismutase , and the severity of AFLD.From January 2012 to December 2013, 162 participants were enrolled in this study and divided into 4 groups: 44 cases of mild AFLD , 55 cases of moderate-to-severe AFLD , 44 cases of alcohol consum...更多

The relationships among inflammation, oxidative balance, and the severity of alcoholic fatty liver disease remain unknown. The aim of this study is to explore the relationships among tumor necrosis factor alpha , heat shock protein 70 , malondialdehyde , superoxide dismutase , and the severity of AFLD.From January 2012 to December 2013, 162 participants were enrolled in this study and divided into 4 groups: 44 cases of mild AFLD , 55 cases of moderate-to-severe AFLD , 44 cases of alcohol consumption without AFLD , and 20 cases of no alcohol consumption without AFLD . A cross-sectional study was conducted by detecting the serum levels of TNF-α, HSP70, MDA, and SOD by enzyme-linked immunosorbent assay.The median serum levels of TNF-α and HSP70 among the 4 groups were statistically significant . The median serum levels of TNF-α in groups A and B were significantly lower than in group C , and the median serum level of TNF-α in group B was significantly lower than in group D . In addition, the median serum level of HSP70 in group B was significantly lower than in groups A and C , and the median serum level of HSP70 in group C was significantly higher than in group D . However, the median serum level of MDA in group B was significantly lower than only group C .Chronic alcohol ingestion without AFLD may result in a significant increase in the circulation of certain inflammatory markers; the severity of AFLD is associated with circulating inflammatory markers, and moderate-to-severe AFLD may result in a more significant reduction of these markers. However, moderate-to-severe AFLD may also result in a significant downregulation of oxidative stress products.收起

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