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作者

Zhang X.-M. Wang Y.-L. Fan W.-Y. Zhang D.-M. Wang Z.-Y. Zhou Y.-M.

作者单位

School of Pharmacy, Taishan Medical University, Taian 271016, China Central Hospital of Xinwen Mining Group, Taian 271219, China

刊名

Chinese Pharmaceutical Journal

年份

2012

卷号

Vol.47 No.24

页码

2000-2003

ISSN

1001-2494

关键词

Estrogen deficiency Osteoporosi Ovariectomized rat Trifolium pratense isoflavone

摘要

OBJECTIVE: To examine the effects of Trifolium pratense isoflavones , the main active component of Trifolium pratense L., on ovariectomy-induced osteoporosis in rats. METHODS: A total of 60 six-month-old female rats were randomly assigned to a sham-operated group and five ovariectomized groups, ie, OVX with vehicle, OVX with graded doses of TPIF, and OVX with nilestriol. The animals were sacrificed after 12-week treatment. RESULTS: Compared to the OVX group, TPIF significantly inhibited the incr...更多

OBJECTIVE: To examine the effects of Trifolium pratense isoflavones , the main active component of Trifolium pratense L., on ovariectomy-induced osteoporosis in rats. METHODS: A total of 60 six-month-old female rats were randomly assigned to a sham-operated group and five ovariectomized groups, ie, OVX with vehicle, OVX with graded doses of TPIF, and OVX with nilestriol. The animals were sacrificed after 12-week treatment. RESULTS: Compared to the OVX group, TPIF significantly inhibited the increase of body weight. In addition, TPIF administration significantly decreased serum levels of alkaline phosphatase and tartrate-resistant acid phosphatase , and increased serum level of estrogen. CONCLUSION: TPIF may be a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis. Its mechanism may be related to increasing estrogen level, inhibiting bone resorption, and promoting bone formation.收起

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