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作者

Xue-Li Li Wei-Dong Cheng Juan Li Yu-Feng Zheng Cun-Ju Guo Sheng-Gang Sun Le-Xin Wang

作者单位

69332905 Corresponding author. Tel.: +61 Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong Province 252000, PR China fax: +86 635 827730 Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong Province 252000, PR China Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong Province 252000, PR China Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong Province 252000, PR China Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong Province 252000, PR China The Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China School of Biomedical Sciences, Charles Sturt University, Boorooma Street, Wagga Wagga, NSW 2678, Australia Corresponding author. Tel.: +86 635 8276215 fax: +61 69 33258

刊名

Biomedicine & Pharmacotherapy

年份

2009

卷号

Vol.63 No.8

页码

599-602

ISSN

0753-3322

关键词

Receptor Estrogen Gene polymorphisms Parkinson's disease Neurology

摘要

This study was designed to investigate the frequency of estrogen receptor gene polymorphism in Chinese patients with Parkinson's disease . Polymerase chain reaction method and restriction fragment length polymorphism were used to detect the ER gene polymorphisms in 158 PD patients and 146 healthy controls. In the PD and control groups, “x” accounted for 83.5% and 80.8%, respectively . “xx” was found in 77.2% of the PD group and in 69.9% of the control group . The frequency of “p” in the PD an...更多

This study was designed to investigate the frequency of estrogen receptor gene polymorphism in Chinese patients with Parkinson's disease . Polymerase chain reaction method and restriction fragment length polymorphism were used to detect the ER gene polymorphisms in 158 PD patients and 146 healthy controls. In the PD and control groups, “x” accounted for 83.5% and 80.8%, respectively . “xx” was found in 77.2% of the PD group and in 69.9% of the control group . The frequency of “p” in the PD and control group was 67.7% and 64.0%, respectively . “pp” was 51.9% in the PD group and 43.8% in the control group . “ppxx” was found in 49.4% of the PD and 43.0% of the control subjects . There was no significant difference in the “x”, “xx”, “p”, “pp” or “ppxx” between males and females within the PD or control groups. In conclusion, we found no significant differences in the genotype or allele frequencies between patients with Parkinson's disease and healthy subjects. These findings suggest that the estrogen receptor gene polymorphism may not play a key role in the pathogenesis PD in Chinese patients.收起

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