Crystal Structure and Activity against Acetaminophen-induced Hepatotoxicity of a Potassium Complex with Taurine-5-bromosalicylaldehyde Schiff Bases

分享到

作者: DIAO Yun-Peng ZHENG Ze-Bao HUANG Shan-Shan ZHANG Hou-Li LIU Ke-Xin LI Kun KANG Ting-Guo

作者单位: College of Pharmacy，Dalian Medical University，Dalian，；China；Department of Chemistry，Taishan University，taian，；China；College of Pharmacy，Dalian Medical University，Dalian，；China；College of Pharmacy，Dalian Medical University，Dalian，；China；College of Pharmacy，Dalian Medical University，Dalian，；China；College of Chemistry and Chemical Engineering，Liaoning Normal；Dalian，Liaoning 116029，China；College of Pharmacy，Liaoning University of Traditional；Dalian，Liaoning 116001，China

摘要: A novel potassium complex KC_9H_9NO_4SBr has been synthesized and charac-terized by IR spectra and single-crystal X-ray diffraction method. The crystal belongs to orthor-hombic, space group Pbca with a=0.74040, b=0.74960, c=4.2620 nm, V= 2.3654 nm~3, M_r = 346.24, D_c = 1.945 g/cm~3, Z= 8, F = 1376, mup = 4.005mm~, GOOF= 1.021, R = 0.0471 and wR = 0.0872. In the crystal, the potassium ion is typically eight-coordinated, surrounded by eight O atoms from six -2-ethane-sulfonate anions. The neighbo...更多; A novel potassium complex KC_9H_9NO_4SBr has been synthesized and charac-terized by IR spectra and single-crystal X-ray diffraction method. The crystal belongs to orthor-hombic, space group Pbca with a=0.74040, b=0.74960, c=4.2620 nm, V= 2.3654 nm~3, M_r = 346.24, D_c = 1.945 g/cm~3, Z= 8, F = 1376, mup = 4.005mm~, GOOF= 1.021, R = 0.0471 and wR = 0.0872. In the crystal, the potassium ion is typically eight-coordinated, surrounded by eight O atoms from six -2-ethane-sulfonate anions. The neighboring potassium ions are bridged by sulfonate groups into a two-dimensional layer structure, above and below which the 5-bromo-2-hydroxy-benzene rings are protruded. The activity against acetaminophen-indueed hepatotoxieity of this complex was also studied, and found it can protect liver from hepatotoxieity induced by acetaminophen to some extent.收起

列表公用js 卡片页统计

相同作者单位文献