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作者

Hou, H. Zhao, Y. Yu, W. Dong, H. Xue, X. Ding, J. Xing, W. Wang, W.

作者单位

School of Basic Medical Science, Taishan Medical University, Taian, China School of Medical and Health Sciences, Edith Cowan University, Perth, Australia a School of Public Health, Taishan Medical University, Taian, China Taishan Hospital of Shandong Province, Taian, China

刊名

Journal of Global Health

年份

2018

卷号

Vol.8 No.1

ISSN

2047-2978;2047-2986

分类号

362

摘要

Background Obstructive sleep apnea is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension. Methods The Preferred Reporting Items for Systematic Reviews and Meta- Analyse...更多

Background Obstructive sleep apnea is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension. Methods The Preferred Reporting Items for Systematic Reviews and Meta- Analyses was followed. PubMed and Embase databases were used for searching the relevant studies published up to December 31, 2016. A quantitative approach of meta-analysis was performed to estimate the pooled odds ratio and 95% confidence interval . Results Twenty-six studies with 51 623 participants met inclusion criteria and were included in this study. Among them, six studies showed a significant association between OSA and resistant hypertension . Meanwhile, the combination of 20 original studies on the association of OSA with essential hypertension also presented significant results with the pooled ORs of 1.184 for mild OSA, 1.316 for moderate OSA and 1.561 for severe OSA. Conclusions Our findings indicated that OSA is related to an increased risk of resistant hypertension. Mild, moderate and severe OSA are associated essential hypertension, as well a dose-response manner relationship is manifested. The associations are relatively stronger among Caucasians and male OSA patients.收起

学科

【SCI学科】PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

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