College of Life Science, Northwest A and F University, Xi'an 712100 Shaanxi Province, ChinaCollege of Life Sciences, Nankai University, Tianjin 300071, Chinaa College of Pharmacology, Taishan Medical University, Taian 271000 Shandong Province, ChinaXi'an Taiming Institute for Pharmacology, Xi'an 710061 Shaanxi Province, China
刊名
Chinese Journal of Clinical Rehabilitation
年份
2005
卷号
Vol.9 No.39
页码
110-111
ISSN
1671-5926
摘要
Aim: To study anti-inflammatory and analgesic effects of aqueous extracts of dioscorea collettii var by foot swollen experiment in mice and rats induced by sodium urate and mice pain experiment due to hot bath. Methods: This experiment was conducted at the Xi'an Taiming Insti tute for Pharmacology from October 2002 to May 2003. The foot swollen experiment included 40 mice and 40 rats, and the animals were assigned randomly into 4 groups, respectively. They were perfused with saline with the same...更多
Aim: To study anti-inflammatory and analgesic effects of aqueous extracts of dioscorea collettii var by foot swollen experiment in mice and rats induced by sodium urate and mice pain experiment due to hot bath. Methods: This experiment was conducted at the Xi'an Taiming Insti tute for Pharmacology from October 2002 to May 2003. The foot swollen experiment included 40 mice and 40 rats, and the animals were assigned randomly into 4 groups, respectively. They were perfused with saline with the same volume, 0.13 g/kg indomethacin suspension, doses of 10 g/ kg and 20 g/kg aqueous extracts of dioscorea collettii var, respectively. Hindfoots of the right side of mice and rats were injected with sodium urate suspension inducing inflammation. The diameter of talocrural joint of inflammatories anklebones was measured at 0.5, 1, 2, 3, 4 and 6 hours. Forty analgesic mice were divided randomly, and the groups and administration were the same to foot swollen experiment. The tails of the mice were put into homeothermia bath with 45 °C temperature at 1 and 2 hours after the last administration, and note the time of mice pushing tail as the pained threshold. Results: 1 Inhibitiv e effects of aqueous extracts of dioscorea collettii var on foot swelling in mice and rats: Dose of 10 g/kg and 20 g/kg aqueous extracts of dioscorea collettii var could decrease significantly the foot swelling in mice after inflammation of mice for 3 or 4 hours, and its effects was the same to indomethacin [it was , , , mm at 3 hours in the saline group, indomethacin group and 10 g/kg and 20 g/kg aqueous extracts of dioscorea collettii var group, respectively; , , , mm,P < 0.05 or 0.01 at 4 hours, respectively]. After inflammation for 3 hours in rats, the foot swelling was decreased significantly [It was , , , mm,P < 0.05 or P < 0.01 in the saline group, indomethacin group and 10 g/kg and 20 g/kg aqueous extracts of dioscorea collettii var group, respectively]. 2 Effects of aqueous extracts of dioscorea collettii var on pain due to hot bath in mice: Dose of 20 g/kg of aqueous extracts of dioscorea collettii var could obviously prolong the time of rebounding tails in mice due to hot bath, enhance threshold value, and its analgesic effects was equal to that in the indomethacin group [Pain threshold value was , , s,P < 0.05 or P < 0.01, respectively in the saline group, indomethacin group and 20 g/kg aqueous extracts of dioscorea collettii var group]. Conclusion: Th e aqueous extracts of dioscorea collettii var can decrease remarkably the foot swelling in mice and rats, heighten pain threshold value in mice and have certain effects on gouty arthritis induced by sodium urate.收起
