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作者

Weifeng Shi Juan Li Hong Zhou George F.Gao

作者单位

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, China. Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong (Taishan Medical College), Taishan Medical College, Taian, 271000, China. Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong (Taishan Medical College), Taishan Medical College, Taian, 271000, China. shiwf@ioz.ac.cn. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. Affiliations

刊名

Science China(Life Sciences)

年份

2017

卷号

Vol.60 No.12

页码

1317-1330

ISSN

1869-1889

关键词

emerging infectious diseases SARS-CoV MERS-CoV genomic surveillance H7N9 Zika Ebola

摘要

In the past twenty years,numerous novel zoonotic viral agents with pandemic potential have emerged in China,such as the severe acute respiratory syndrome coronavirus and,more recently,the avian-origin influenza A/H7N9 virus,which have caused outbreaks among humans with high morbidity and mortality.In addition,several emerging and re-emerging viral pathogens have also been imported into China from travelers,e.g.the Middle East respiratory syndrome coronavirus and Zika virus .Herein,we review th...更多

In the past twenty years,numerous novel zoonotic viral agents with pandemic potential have emerged in China,such as the severe acute respiratory syndrome coronavirus and,more recently,the avian-origin influenza A/H7N9 virus,which have caused outbreaks among humans with high morbidity and mortality.In addition,several emerging and re-emerging viral pathogens have also been imported into China from travelers,e.g.the Middle East respiratory syndrome coronavirus and Zika virus .Herein,we review these emerging viral pathogens in China and focus on how surveillance by pathogen genomics has been employed to discover and annotate novel pathogenic agents,identify natural reservoirs,monitor the transmission events and delineate their evolution and adaption to the human host.We also highlight the application of genomic sequencing in the recent Ebola epidemics in Western Africa.In summary,genomic sequencing has become a standard research tool in the field of emerging infectious diseases which has been proven invaluable in containing these viral infections and reducing burden of disease in humans and animals.Genomic surveillance of pathogenic agents will serve as a key epidemiological and research tool in the modern era of precision infectious diseases and in the future studies of virosphere.收起

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