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作者单位

Office of Director-General,Chinese Center for Disease Control and Prevention (China CDC),Beijing,China Shenzhen Key Laboratory of Pathogen and Immunity,Shenzhen Third People’s Hospital,Shenzhen,China Center for Influenza Research and Early-Warning (CASCIRE),Chinese Academy of Sciences,Beijing,China Yiwu Center for Disease Control and Prevention,Yiwu,China CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology,Chinese Academy of Sciences,Beijing,China Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,China Institute of Pathogen Biology,Taishan Medical College,Taian,China

刊名

蛋白质与细胞

年份

2016

卷号

No.6

摘要

Dear Editor, First discovered during 1947 in Uganda from febrile rhesus macaques,Zika virus is a mosquito-bome,reemerging flavivirus historically known to be present in much of Africa and Asia,occasionally causing outbreaks amongst the local populace .ZIKV infections in humans are mostly asymptomatic,but a small percentage of patients may show clinical symptoms such as a fever and rash,which resolve within a week or less.Due to the benign nature of the disease,ZIKV was considered an obscure and...更多

Dear Editor, First discovered during 1947 in Uganda from febrile rhesus macaques,Zika virus is a mosquito-bome,reemerging flavivirus historically known to be present in much of Africa and Asia,occasionally causing outbreaks amongst the local populace .ZIKV infections in humans are mostly asymptomatic,but a small percentage of patients may show clinical symptoms such as a fever and rash,which resolve within a week or less.Due to the benign nature of the disease,ZIKV was considered an obscure and neglected pathogen of low public health consequence.Recently,viral infection of women during pregnancy have been associated with microcephaly in their offspring ,and neurological disorders such as Guillain-Barré syndrome have also been associated with prior ZIKV infections .Moreover,the ZIKV nonstructural protein 1 has diverse electrostatic characteristics at host-interaction interfaces .These new findings,in addition to the persistence of ZIKV in the semen of infected patients and possible sexual transmission of the virus suggest that this virus may be more dangerous than initially thought.收起

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