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作者

Zhang Yanjun Chen Wenxian Wong Gary Bi Yuhai Yan Juying Sun Yi Chen Enfu Yan Hao Lou Xiuyu Mao Haiyan Xia Shichang Gao George F Shi Weifeng Chen Zhiping

作者单位

Zhejiang Provincial Center for Disease Control and Prevention，Hangzhou，310051；Yiwu Center for Disease Control and Prevention，Yiwu，322000；Institute of Microbiology，Chinese Academy of Sciences，CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI)，Beijing，100101；Institute of Pathogen Biology，Taishan Medical College，Taian，271000

刊名

Protein & Cell

年份

2016

卷号

第7卷

期号

第6期

页码

461-464

ISSN

1674-800X

关键词

discovered Uganda macaques

摘要

First discovered during 1947 in Uganda from febrile rhesus macaques, Zika virus is a mosquito-borne, reemerging flavivirus historically known to be present in much of Africa and Asia, occasionally causing outbreaks amongst the local populace . ZIKV infections in humans are mostly asymptomatic, but a small percentage of patients may show clinical symptoms such as a fever and rash, which resolve within a week or less. Due to the benign nature of the disease, ZIKV was considered an obscure and neg...更多

First discovered during 1947 in Uganda from febrile rhesus macaques, Zika virus is a mosquito-borne, reemerging flavivirus historically known to be present in much of Africa and Asia, occasionally causing outbreaks amongst the local populace . ZIKV infections in humans are mostly asymptomatic, but a small percentage of patients may show clinical symptoms such as a fever and rash, which resolve within a week or less. Due to the benign nature of the disease, ZIKV was considered an obscure and neglected pathogen of low public health consequence. Recently, viral infection of women during pregnancy have been associated with microcephaly in their offspring , and neurological disorders such as Guillain-Barre syndrome have also been associated with prior ZIKV infections . Moreover, the ZIKV nonstructural protein 1 has diverse electrostatic characteristics at host-interaction interfaces . These new findings, in addition to the persistence of ZIKV in the semen of infected patients and possible sexual transmission of the virus suggest that this virus may be more dangerous than initially thought.收起

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