Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014

Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014–2015

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作者: Bi, Yuhai Chen, Jianjun Zhang, Zhenjie Li, Mingxin Cai, Tianlong Sharshov, Kirill Susloparov, Ivan Shestopalov, Alexander Wong, Gary He, Yubang Xing, Zhi Sun, Jianqing Liu, Di Liu, Yingxia Liu, Lei Liu, Wenjun Lei, Fumin Shi, Weifeng Gao, George F.

作者单位: ^hQinghai Lake National Nature Reserve, State Forestry Administration, Xining, 810007, China ^cCAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China ^fCenter for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, 100101, China ^dInstitute of Pathogen Biology, Taishan Medical College, Taishan, 271000, China ⁱOffice of Director-General, Chinese Center for Disease Control and Prevention (China CDC), and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Zhejiang University, Hangzhou, 310058, China ^aShenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen, 518112, China ^eCAS Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China ^gResearch Institute of Experimental and Clinical Medicine, Novosibirsk State University, Novosibirsk, 630090, Russian Federation ^bCAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology Chinese Academy of Sciences, Wuhan, 430071, China

关键词: Clade 2.3.2.1c H5N1 highly pathogenic avian influenza virus migratory birds outbreak

摘要: A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain . Further analysis showed that similar viruses have been circulating in wild...更多; A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain . Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai , Bulgaria and Romania , as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans.收起

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