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作者

Bi, Yuhai Chen, Quanjiao Wang, Qianli

作者单位

20 Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China 17 Taishan Med Coll, Inst Pathogen Biol, Tai An 271016, Shandong, Peoples R China 12 Novosibirsk State Univ, Res Inst Expt & Clin Med, Novosibirsk 630090, Russia BGI Shenzhen, China Natl Genebank Shenzhen, Shenzhen 518083, Peoples R China 13 South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China 16 Guangxi Univ, Coll Anim Sci & Vet Med, Lab Anim Infect Dis, Nanning 530004, Peoples R China 15 Chinese Ctr Dis Control & Prevent, Key Lab Surveillance & Early Warning Infect Dis, Div Infect Dis, Beijing 102206, Peoples R China 14 Tsinghua Univ, Ctr Earth Syst Sci, Key Lab Earth Syst Modelling, Minist Educ, Beijing 100084, Peoples R China Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China 18 Chinese Acad Sci, Inst Microbiol, Network Informat Ctr, Beijing 100101, Peoples R China Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China Shenzhen Third Peoples Hosp, State Key Discipline Infect Dis, Shenzhen Key Lab Pathogen & Immun, Shenzhen 518112, Peoples R China 10 Natl Res Ctr Vet Med, Luoyang 471003, Peoples R China Chinese Acad Sci, Inst Microbiol, Collaborat Innovat Ctr Diag & Treatment Infect Di, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China Jilin Univ, Coll Vet Med, Dept Vet Prevent Med, Changchun 130062, Jilin, Peoples R China 11 Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350003, Peoples R China Diqing Tibetan Autonomous Prefecture Ctr Dis Cont, Shangri La 674400, Peoples R China 19 Broad Inst Harvard & MIT, Cambridge, MA 02142 USA Yunnan Ctr Dis Control & Prevent, Kunming 650022, Peoples R China

刊名

Cell Host & Microbe

年份

2016

卷号

Vol.20 No.6

页码

810-821

ISSN

1931-3128;1931-3128

关键词

LIVE POULTRY MARKETS SHORT READ ALIGNMENT MIGRATORY BIRDS HUMAN INFECTION A VIRUSES A(H5N6) VIRUS H7N9 VIRUS HONG-KONG ORIGIN H9N2

摘要

Constant surveillance of live poultry markets is currently the best way to predict and identify emerging avian influenza viruses that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylo...更多

Constant surveillance of live poultry markets is currently the best way to predict and identify emerging avian influenza viruses that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific. H5N6 viruses constitute at least 34 distinct genotypes derived from various evolutionary pathways. Notably, genotype G1.2 virus, with internal genes from the chicken H9N2/H7N9 gene pool, was responsible for at least five human H5N6 infections. Our findings highlight H5N6 AIVs as potential threats to public health and agriculture.收起

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