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作者

YouCan Zhang, ZhongSheng Li, Yun Ma, Zhen Mu

作者单位

Department of Dermatology, The First People's Hospital of Taian, Tai'an, 271000, Shandong, China. Department of Dermatology, The Second Affiliated Hospital of Shandong First Medical University, No. 706 Taishan Street, Tai'an, 271000, Shandong Province, China. muzhen@sina.com. Tai'an City Daiyue District Skin Disease Prevention and Control, Tai'an, 271000, Shandong, China. Affiliations Department of Dermatology, Tai'an City Central Hospital, Tai'an, 271000, Shandong, China.

刊名

Clinical rheumatology

年份

2019

卷号

Vol.38 No.10

页码

2659-2671

ISSN

1434-9949

关键词

Catalase Malondialdehyde Meta-analysis Oxidative stress Psoriasis Total antioxidant status Total oxidant status.

摘要

Although oxidative stress plays a major role in psoriasis, the association between oxidative stress biomarker levels and psoriasis in humans remains controversial. Relevant articles were retrieved by searching the following databases: PubMed, Web of Science, and EMBASE, without any time limit . The pooled weighted mean difference and 95% confidence interval for the total oxidant status , total antioxidant status , malondialdehyde , and catalase were calculated for each study. Heterogeneity te...更多

Although oxidative stress plays a major role in psoriasis, the association between oxidative stress biomarker levels and psoriasis in humans remains controversial. Relevant articles were retrieved by searching the following databases: PubMed, Web of Science, and EMBASE, without any time limit . The pooled weighted mean difference and 95% confidence interval for the total oxidant status , total antioxidant status , malondialdehyde , and catalase were calculated for each study. Heterogeneity test, publication bias analysis, and sensitivity analysis were performed. A total of 28 case-control studies, containing a combined total of 2724 subjects , were enrolled in this meta-analysis. The combined results showed a significant difference in the TAS levels , TOS levels , MDA levels , and CAT levels between psoriasis patients and controls. Moreover, the combined results showed a significant difference in the TAS, MDA, and CAT levels in patients with mild vs. moderate psoriasis and moderate vs. severe psoriasis. TAS and CAT levels in psoriasis patients were significantly lower than in healthy controls, whereas the TOS and MDA levels were significantly higher. Furthermore, the TAS, MDA, and CAT levels are associated with the severity of disease. These results indicate that redox imbalances play a major role in the pathogenesis of psoriasis.收起

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