获取途径

作者

Xiaotong Xia Nianxu Huang Boxia Li Yan Li Lang Zou Dongdong Yuan Banghua Huang Yufei Bei Yuxin Liu Jinglan Fu Tingting Wu Wenjun Chen Shaojun Jiang Meina Lv Jinhua Zhang

作者单位

Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated With Shandong First Medical University, Jinan, Shangdong, China Department of Pharmacy, Second Affiliated Hospital, Army Medical University, Chongqing, China Department of Pharmacy, Wuhan Asian Heart Hospital, Wuhan, Hubei, China Department of Pharmacy, the First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China 10 Department of Pharmacy, Huaihe Hospital of He-Nan University, Kaifeng, Henan, China Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, China Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China Department of Pharmacy, The First Hospital of Lanzhou University, Lanzhou, Gansu, China College of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China Department of Pharmacy, Zhengzhou Seventh People’s Hospital, Zhengzhou, Henan, China

刊名

European Journal of Clinical Pharmacology

年份

2022

卷号

Vol.78 No.1

页码

43-51

ISSN

0031-6970

关键词

Warfarin Gene polymorphism CYP2C9 VKORC1 Model

摘要

Purpose The purpose of this paper is to study the correlation between demographic and clinical factors and warfarin dose of patients in Chinese Han population taking warfarin and study gene polymorphisms impact of related gene loci on warfarin doses, to establish a model to predict initial standard dose and maintenance dose based on CYP2C9*3 , VKORC1-1639G  >  A genotype. Methods The study collects the data of patients in our hospital and other subcenters which incorporates 2160 patients ...更多

Purpose The purpose of this paper is to study the correlation between demographic and clinical factors and warfarin dose of patients in Chinese Han population taking warfarin and study gene polymorphisms impact of related gene loci on warfarin doses, to establish a model to predict initial standard dose and maintenance dose based on CYP2C9*3 , VKORC1-1639G  >  A genotype. Methods The study collects the data of patients in our hospital and other subcenters which incorporates 2160 patients to establish the initial dose model and 1698 patients for the stable dose model, and sequences 26 multigene sites in 451 patients. Based on the patient’s dosage, clinical data, and demographic characteristics, the genetic and non-genetic effects on the initial dose and stable dose of warfarin are calculated by using statistical methods, and the prediction model of initial standard dose and maintenance dose can be established via multiple linear regression. Results The initial dose of warfarin was calculated as − 0.273 ×  + 0.245 ×  − 0.003 ×  − 0.036 ×  + 0.021 × ) 2 . This model incorporated seven factors and explained 55.3% of the individualization differences of the warfarin drug dose. The maintenance dose of warfarin was calculated as  + 0.480 ×  − 0.214 ×  − 0.074 ×  − 0.003 ×  − 0.077 ×  − 0.002 × ) 2 . This model incorporated six factors and explained 42.4% of the individualization differences in the warfarin drug dose. Conclusion The genetic and non-genetic factors affecting warfarin dose in Chinese Han population were studied systematically in this study. The pharmacogenomic dose prediction model constructed in this study can predict anticoagulant efficacy of warfarin and has potential application value in clinical practice.收起

文献类型

期刊

浏览量

19