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作者

Kunrong Wu Shufang Zhang Ziwan Guan Xiaoli Li Rui Li Ying Yin Yan Li

作者单位

Department of Clinical Pharmacy，The First Affiliated Hospital of Shandong First Medical University，Jinan 250014，China；School of Pharmaceutical Sciences，Shandong First Medical University(Shandong Academy of Medical Sciences)Tai'an 271000，Shandong，China

刊名

中国医学科学杂志(英文版)

年份

2021

卷号

第36卷

期号

第2期

页码

103-109

ISSN

1001-9294

关键词

methylenetetrahydrofolate reductase gene polymorphism type 2 diabetes mellitus coronary heart diseases homocysteine

摘要

Objective Chronic cardiovascular diseases induced by long-term poor blood glucose control are the main cause of death in patients with type 2 diabetes mellitus . Previous researches report that methylenetetrahydrofolate reductase gene polymorphisms might influence the occurrence of coronary heart disease in T2DM patients. The purpose of this study was to evaluate whether MTHFR C677T and A1298C mutations are associated with the risk of CHD in T2DM patients. Methods A total of 197 subjects with ...更多

Objective Chronic cardiovascular diseases induced by long-term poor blood glucose control are the main cause of death in patients with type 2 diabetes mellitus . Previous researches report that methylenetetrahydrofolate reductase gene polymorphisms might influence the occurrence of coronary heart disease in T2DM patients. The purpose of this study was to evaluate whether MTHFR C677T and A1298C mutations are associated with the risk of CHD in T2DM patients. Methods A total of 197 subjects with T2DM were studied, of which 95 patients with CHD. The genotypes of MTHFR C677T and A1298C were analyzed by using dideoxy chain-termination method, and compared between patients with CHD and those without CHD. Results We found that the frequency of the 677T allele was significantly higher in T2DM patients with CHD than those without CHD . However, there was no significant difference in any of the examined haplotypes between T2DM patients with and without CHD. Furthermore, the 677T allele was associated with a higher risk of CHD development in diabetic patients with lower homocysteine levels , while no effect of MTHFR gene polymorphism on the incidence of CHD was found in patients with higher Hcy levels . Conclusion The MTHFR C677T gene polymorphism is associated with the risk of CHD of diabetic patients and could be used as an effective marker for CHD in Chinese diabetic populations with normal Hcy levels收起

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