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作者

Tao Li, Chun-Lin Yang, Tong Du, Peng Zhang, Yang Zhou, Xiao-Li Li, Cong-Cong Wang, Ying Liu, Heng Li, Min Zhang, Rui-Sheng Duan

作者单位

Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, China Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, Shandong 250014, China. Electronic address: ruisheng_duan@16 Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, Shandong 250014, China. ³ Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, China. ⁴ Department of Neurology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, China Shandong Institute of Neuroimmunology, Jinan, Shandong 250014, China com. Affiliations ¹ Department of Neurology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, China. ² Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, China

刊名

Clinical immunology (Orlando, Fla.)

年份

2022

页码

109141

ISSN

1521-7035

关键词

Circulating follicular helper T (Tfh) cells Diabetes mellitus Hyperglycemia Mechanistic target of rapamycin (mTOR) signaling Myasthenia gravis.

摘要

Myasthenia gravis is a T-cell-dependent, antibody-mediated autoimmune disease. Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia and emerging evidence indicates its profound impacts on the immune homeostasis. Previous studies and our data showed DM might serve as an independent risk factor of MG, yet the underlying immune and molecular mechanisms remain to be addressed. Our study observed that circulating Tfh cells were increased in MG patients with DM and expres...更多

Myasthenia gravis is a T-cell-dependent, antibody-mediated autoimmune disease. Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia and emerging evidence indicates its profound impacts on the immune homeostasis. Previous studies and our data showed DM might serve as an independent risk factor of MG, yet the underlying immune and molecular mechanisms remain to be addressed. Our study observed that circulating Tfh cells were increased in MG patients with DM and expressed a high level of ICOS. Besides, positive correlations between activated cTfh cells and plasmablasts were documented. Further studies demonstrated hyperglycemia promoted the differentiation and activation of Tfh cells which, in turn, caused abnormal plasmablasts differentiation and antibody secretion through the mTOR signaling pathway. These results indicated DM might aggravate the aberrant humoral immunity in MG patients by augmenting Tfh cells differentiation and function and tight glycemic control might be beneficial for MG patients with DM.收起

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