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作者

Lian-Peng Zhang, Xiao-Xia Zhang

作者单位

Affiliations ¹ Department of Respiratory Medicine, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou People's Hospital, Qingzhou 262500, Shandong Province, China. hxzlp2013@12 com. ² Department of AIDS Voluntary Counseling and Testing, Qingzhou Center for Disease Control and Prevention, Qingzhou 262500, Shandong Province, China.

刊名

World journal of clinical cases

年份

2022

卷号

Vol.10 No.31

页码

11403-11410

ISSN

2307-8960

关键词

Lipid Mendelian randomization Risk factor Single nucleotide polymorphism Sleep apnea.

摘要

Background: Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive. Aim: To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization analysis. Methods: Single nucleotide polymorphism data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578 individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the Un...更多

Background: Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive. Aim: To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization analysis. Methods: Single nucleotide polymorphism data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578 individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the United Kingdom Biobank study, which comprised 463005 individuals of European ancestry. Two-sample MR analysis was performed to assess the causality between serum lipids and sleep apnea based on the above public data. Results: Genetically predicted low-density lipoprotein , high-density lipoprotein , triglyceride , and total cholesterol were causally unrelated to sleep apnea. Conclusion: Our MR analysis suggests that genetically predicted serum lipids are not risk factors of sleep apnea.收起

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