Affiliations 1 Department of Respiratory Medicine, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou People's Hospital, Qingzhou 262500, Shandong Province, China. hxzlp2013@12com. 2 Department of AIDS Voluntary Counseling and Testing, Qingzhou Center for Disease Control and Prevention, Qingzhou 262500, Shandong Province, China.
Background: Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive. Aim: To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization analysis. Methods: Single nucleotide polymorphism data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578 individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the Un...更多
Background: Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive. Aim: To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization analysis. Methods: Single nucleotide polymorphism data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578 individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the United Kingdom Biobank study, which comprised 463005 individuals of European ancestry. Two-sample MR analysis was performed to assess the causality between serum lipids and sleep apnea based on the above public data. Results: Genetically predicted low-density lipoprotein , high-density lipoprotein , triglyceride , and total cholesterol were causally unrelated to sleep apnea. Conclusion: Our MR analysis suggests that genetically predicted serum lipids are not risk factors of sleep apnea.收起
