1Department of Respiratory Medicine, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou People's Hospital；2Department of AIDS Voluntary Counseling and Testing, Qingzhou Center for Disease Control and Prevention
刊名
World Journal of Clinical Cases
年份
2022
卷号
第10卷
期号
第31期
页码
11403-11410
ISSN
2307-8960
分类号
R766
摘要
BACKGROUND Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive.AIM To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization analysis.METHODS Single nucleotide polymorphism data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the United Kin...更多
BACKGROUND Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive.AIM To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization analysis.METHODS Single nucleotide polymorphism data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the United Kingdom Biobank study, which comprised 463005individuals of European ancestry. Two-sample MR analysis was performed to assess the causality between serum lipids and sleep apnea based on the above public data.RESULTS Genetically predicted low-density lipoprotein, high-density lipoprotein, triglyceride, and total cholesterol were causally unrelated to sleep apnea.CONCLUSION Our MR analysis suggests that genetically predicted serum lipids are not risk factors of sleep apnea.收起
