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作者

Lian-Peng Zhang Xiao-Xia Zhang

作者单位

¹Department of Respiratory Medicine, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou People's Hospital；²Department of AIDS Voluntary Counseling and Testing, Qingzhou Center for Disease Control and Prevention

刊名

World Journal of Clinical Cases

年份

2022

卷号

第10卷

期号

第31期

页码

11403-11410

ISSN

2307-8960

分类号

R766

摘要

BACKGROUND Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive.AIM To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization analysis.METHODS Single nucleotide polymorphism data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the United Kin...更多

BACKGROUND Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive.AIM To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization analysis.METHODS Single nucleotide polymorphism data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the United Kingdom Biobank study, which comprised 463005individuals of European ancestry. Two-sample MR analysis was performed to assess the causality between serum lipids and sleep apnea based on the above public data.RESULTS Genetically predicted low-density lipoprotein, high-density lipoprotein, triglyceride, and total cholesterol were causally unrelated to sleep apnea.CONCLUSION Our MR analysis suggests that genetically predicted serum lipids are not risk factors of sleep apnea.收起

学科

【教育部学科】医学

文献类型

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